Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expressed in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.

DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.


Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.

This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.

 Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation

Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.

Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.

ExoPure? Mini Chromatography Columns

K1247-10 each
EUR 874.8

ExoPure? Mini Chromatography Columns

K1247-20 each
EUR 1214.4

ExoPure? Maxi Chromatography Columns

K1248-3 each
EUR 1104

ExoPure? Maxi Chromatography Columns

K1248-6 each
EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)

K1237-10 each
EUR 796.8

ExoPure? Isolation Kit   (Cell Media)

K1237-2 each
EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10 each
EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2 each
EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10 each
EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2 each
EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10 each
EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2 each
EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10 each
EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20 each
EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5 each
EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1015-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3 each
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5 each
EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T each
EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3 each
EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5 each
EUR 796.8

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)

MBS1247989-INQUIRE INQUIRE Ask for price

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)

MBS7014432-002mg 0.02mg
EUR 2195

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)

MBS7014432-01mg 0.1mg
EUR 3115

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)

MBS7014432-5x01mg 5x0.1mg
EUR 13980

Exophilin 5 (EXPH5) Antibody

abx232909-100ug 100 ug
EUR 661.2

Exophilin 5 (EXPH5) Antibody

20-abx313705
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody

abx232909-100g 100 µg
EUR 350

Exophilin 5 (EXPH5) Antibody

abx313705-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody

abx313705-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody

abx313705-50g 50 µg
EUR 250

Mouse Exophilin 5 (EXPH5) ELISA Kit

abx389223-96tests 96 tests
EUR 1093.2

Human Exophilin 5 (EXPH5) ELISA Kit

abx387228-96tests 96 tests
EUR 1093.2

Exophilin 5 (EXPH5) Antibody (HRP)

20-abx313706
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-48T 48T Ask for price

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-96T 96T Ask for price

Human Exophilin 5,EXPH5 ELISA KIT

E2683Hu-1096T 10*96T
EUR 4122

Human Exophilin 5,EXPH5 ELISA KIT

E2683Hu-48wells 48 wells
EUR 300

Human Exophilin 5,EXPH5 ELISA KIT

E2683Hu-596T 5*96T
EUR 2061

Human Exophilin 5,EXPH5 ELISA KIT

E2683Hu-96wells 96 wells
EUR 458

Mouse Exophilin- 5, Exph5 ELISA KIT

ELI-26993m 96tests
EUR 736

Human Exophilin- 5, EXPH5 ELISA KIT

ELI-47267h 96tests
EUR 696

Human Exophilin 5(EXPH5)ELISA Kit

QY-E04934 96T
EUR 433.2

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-50g 50 µg
EUR 250

Illustra Exoprostar 100 RCN - EACH

US78210 EACH
EUR 98.55

Illustra Exoprostar 500 RCN - EACH

US78211 EACH
EUR 376.65

Illustra Exoprostar 2000 RCN - EACH

US78212 EACH
EUR 1347.3

Human Exophilin 5 (EXPH5) ELISA Kit

MBS9302509-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Exophilin 5 (EXPH5) ELISA Kit

MBS9302509-48StripWells 48-Strip-Wells
EUR 550

Human Exophilin 5 (EXPH5) ELISA Kit

MBS9302509-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Exophilin 5 (EXPH5) ELISA Kit

MBS9302509-96StripWells 96-Strip-Wells
EUR 765

Human Exophilin 5 (EXPH5) ELISA Kit

MBS162932-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human Exophilin 5 (EXPH5) ELISA Kit

MBS162932-48StripWells 48-Strip-Wells
EUR 285

Human Exophilin 5 (EXPH5) ELISA Kit

MBS162932-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human Exophilin 5 (EXPH5) ELISA Kit

MBS162932-96StripWells 96-Strip-Wells
EUR 425

Human Exophilin 5 (EXPH5)ELISA Kit

201-12-2684 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

EXO-Prep for exosome isolation from Urine

HBM-EXP-U25 30 ml (25 react)
EUR 234.36

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP), partial

MBS7060111-INQUIRE INQUIRE Ask for price

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (AP)

MBS6416475-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (AP)

MBS6416475-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (PE)

MBS6416485-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (PE)

MBS6416485-5x01mL 5x0.1mL
EUR 4120

Exophilin 5 (EXPH5) Antibody (FITC)

20-abx313707
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-50g 50 µg
EUR 250

Human Exophilin-5, EXPH5 ELISA Kit

MBS9331358-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Exophilin-5, EXPH5 ELISA Kit

MBS9331358-48StripWells 48-Strip-Wells
EUR 550

Human Exophilin-5, EXPH5 ELISA Kit

MBS9331358-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Exophilin-5, EXPH5 ELISA Kit

MBS9331358-96StripWells 96-Strip-Wells
EUR 765

Mouse Exophilin-5, EXPH5 ELISA Kit

MBS9339734-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Exophilin-5, EXPH5 ELISA Kit

MBS9339734-48StripWells 48-Strip-Wells
EUR 550

Mouse Exophilin-5, EXPH5 ELISA Kit

MBS9339734-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Exophilin-5, EXPH5 ELISA Kit

MBS9339734-96StripWells 96-Strip-Wells
EUR 765

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (APC)

MBS6416476-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (APC)

MBS6416476-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (FITC)

MBS6416478-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (FITC)

MBS6416478-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (HRP)

MBS6416479-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (HRP)

MBS6416479-5x01mL 5x0.1mL
EUR 4120

EXO-Prep for exosome isolation from Cell Media

HBM-EXP-C25 25 ml (25 react)
EUR 234.36

Illustra ExoPro S 100 Reactions - EACH

US79010 EACH
EUR 90.45

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (Biotin)

MBS6416477-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (Biotin)

MBS6416477-5x01mL 5x0.1mL
EUR 4120

Exophilin 5 (EXPH5) Antibody (Biotin)

20-abx313708
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-50g 50 µg
EUR 250

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 405)

MBS6416480-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 405)

MBS6416480-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 490)

MBS6416481-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 490)

MBS6416481-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 550)

MBS6416482-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 550)

MBS6416482-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 650)

MBS6416483-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 650)

MBS6416483-5x01mL 5x0.1mL
EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 750)

MBS6416484-01mL 0.1mL
EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 750)

MBS6416484-5x01mL 5x0.1mL
EUR 4120

Human Exophilin 5, EXPH5 GENLISA ELISA

KBH2683 1 x 96 wells
EUR 286

EXO-Prep for exosome isolation from Plasma and serum

HBM-EXP-B5 5 ml
EUR 181.44

EXPH5 (untagged)-Human exophilin 5 (EXPH5)

SC309119 10 µg Ask for price

EXPH5 (GFP-tagged) - Human exophilin 5 (EXPH5)

RG218060 10 µg Ask for price

Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.