Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expresse d in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.
DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.
Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.
This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation
Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.
Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.
ExoPure? Mini Chromatography Columns
K1247-10
Biovision
each
EUR 874.8
ExoPure? Mini Chromatography Columns
K1247-20
Biovision
each
EUR 1214.4
ExoPure? Maxi Chromatography Columns
K1248-3
Biovision
each
EUR 1104
ExoPure? Maxi Chromatography Columns
K1248-6
Biovision
each
EUR 1690.8
ExoPure? Isolation Kit (Cell Media)
K1237-10
Biovision
each
EUR 796.8
ExoPure? Isolation Kit (Cell Media)
K1237-2
Biovision
each
EUR 470.4
ExoPure? Isolation Kit (Bio Fluids)
K1241-10
Biovision
each
EUR 836.4
ExoPure? Isolation Kit (Bio Fluids)
K1241-2
Biovision
each
EUR 483.6
ExoPure? Isolation Kit (Serum, Plasma)
K1238-10
Biovision
each
EUR 836.4
ExoPure? Isolation Kit (Serum, Plasma)
K1238-2
Biovision
each
EUR 470.4
ExoPure? Isolation Kit (Stem Cell Media)
K1239-10
Biovision
each
EUR 901.2
ExoPure? Isolation Kit (Stem Cell Media)
K1239-2
Biovision
each
EUR 510
ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-25
Biovision
each
EUR 992.4
ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-50
Biovision
each
EUR 1083.6
ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-25
Biovision
each
EUR 992.4
ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-50
Biovision
each
EUR 1083.6
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-10
Biovision
each
EUR 796.8
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-20
Biovision
each
EUR 1260
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-5
Biovision
each
EUR 633.6
ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
M1007-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
M1008-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)
M1009-100-B
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1010-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1011-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1012-100-B
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1013-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1014-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1015-100-B
Biovision
each
EUR 888
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-10
Biovision
each
EUR 1005.6
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-20
Biovision
each
EUR 1546.8
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-3
Biovision
each
EUR 523.2
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-5
Biovision
each
EUR 796.8
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)
M1004-100-T
Biovision
each
EUR 1136.4
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)
M1005-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)
M1006-100-B
Biovision
each
EUR 888
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1030-10
Biovision
each
EUR 1005.6
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1030-20
Biovision
each
EUR 1546.8
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1030-3
Biovision
each
EUR 529.2
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5
Biovision
each
EUR 796.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1031-10
Biovision
each
EUR 1005.6
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1031-20
Biovision
each
EUR 1546.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1031-3
Biovision
each
EUR 523.2
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5
Biovision
each
EUR 796.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)
M1039-10
Biovision
each
EUR 1005.6
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)
M1039-20
Biovision
each
EUR 1546.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)
M1039-3
Biovision
each
EUR 523.2
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)
M1039-5
Biovision
each
EUR 796.8
Exophilin 5 (EXPH5) Antibody
20-abx313705
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Exophilin 5 (EXPH5) Antibody
abx232909-100ug
Abbexa
100 ug
EUR 661.2
Exophilin 5 (EXPH5) Antibody (HRP)
20-abx313706
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Mouse Exophilin 5 (EXPH5) ELISA Kit
abx389223-96tests
Abbexa
96 tests
EUR 1093.2
Human Exophilin 5 (EXPH5) ELISA Kit
abx387228-96tests
Abbexa
96 tests
EUR 1093.2
Human Exophilin 5 (EXPH5)ELISA Kit
201-12-2684
SunredBio
96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Exophilin 5 (EXPH5) Antibody (FITC)
20-abx313707
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Exophilin 5 (EXPH5) Antibody (Biotin)
20-abx313708
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit
EF014853
Lifescience Market
96 Tests
EUR 826.8
Exopolyphosphatase (PPX1) Antibody
20-abx300871
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Exopolyphosphatase (PPX1) Antibody (HRP)
20-abx300912
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Exopolyphosphatase (PPX1) Antibody (FITC)
20-abx300913
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-EP360285EGX
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in E.coli
Escherichia coli Exopolyphosphatase (ppx)
1-CSB-EP365319ENV
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Escherichia coli Exopolyphosphatase(ppx) expressed in E.coli
Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-YP360285EGX
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in Yeast
Exopolyphosphatase (PPX1) Antibody (Biotin)
20-abx300914
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Prune Exopolyphosphatase 1 (PRUNE1) Antibody
20-abx334087
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
20-abx337306
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
20-abx337307
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
20-abx337308
Abbexa
EUR 493.20
EUR 2214.00
EUR 718.80
EUR 218.40
EUR 360.00
100 ug
1 mg
200 ug
20 ug
50 ug
Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
1-CSB-EP334459SVG
Cusabio
EUR 733.20
EUR 370.80
EUR 2192.40
EUR 1126.80
EUR 1461.60
EUR 476.40
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in E.coli
Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
1-CSB-YP334459SVG
Cusabio
EUR 814.80
EUR 402.00
EUR 2606.40
EUR 1261.20
EUR 1730.40
EUR 522.00
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in Yeast
Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-100ug
Biomatik Corporation
100ug
EUR 721.6
Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-20ug
Biomatik Corporation
20ug
EUR 448.1
Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-100ug
Biomatik Corporation
100ug
EUR 721.6
Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-20ug
Biomatik Corporation
20ug
EUR 448.1
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-10ug
QP7336-ec-10ug
EnQuireBio
10ug
EUR 391.2
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-1mg
QP7336-ec-1mg
EnQuireBio
1mg
EUR 2763.6
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-50ug
QP7336-ec-50ug
EnQuireBio
50ug
EUR 522
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-10ug
QP7169-ec-10ug
EnQuireBio
10ug
EUR 391.2
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-1mg
QP7169-ec-1mg
EnQuireBio
1mg
EUR 2763.6
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-50ug
QP7169-ec-50ug
EnQuireBio
50ug
EUR 522
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-100ug
QP7336-ec-100ug
EnQuireBio
100ug
EUR 848.4
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-200ug
QP7336-ec-200ug
EnQuireBio
200ug
EUR 1338
Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-500ug
QP7336-ec-500ug
EnQuireBio
500ug
EUR 1816.8
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-100ug
QP7169-ec-100ug
EnQuireBio
100ug
EUR 848.4
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-200ug
QP7169-ec-200ug
EnQuireBio
200ug
EUR 1338
Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-500ug
QP7169-ec-500ug
EnQuireBio
500ug
EUR 1816.8
Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-100ug
Biomatik Corporation
100ug
EUR 721.6
Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-1mg
Biomatik Corporation
1mg
EUR 2884.7
Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-20ug
Biomatik Corporation
20ug
EUR 448.1
Exo70 (Exo70) Antibody
abx232892-100ug
Abbexa
100 ug
EUR 577.2
Exo70 antibody
E39-02892
EnoGene
100ug/100ul
EUR 225
Description: Available in various conjugation types.
anti- Exo70 antibody
FNab02892
FN Test
100µg
EUR 606.3
Description: Antibody raised against Exo70
Exonuclease V / EXO5 / DEM1
F54546-0.08ML
NSJ Bioreagents
0.08 ml
EUR 140.25
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]
Exonuclease V / EXO5 / DEM1
F54546-0.4ML
NSJ Bioreagents
0.4 ml
EUR 322.15
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]
Exo1
B6876-10
ApexBio
10 mg
EUR 150
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.
Exo1
B6876-100
ApexBio
100 mg
EUR 619.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.
Exo1
B6876-5.1
ApexBio
10 mM (in 1mL DMSO)
EUR 158.4
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.
Exo1
B6876-50
ApexBio
50 mg
EUR 385.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.
Exo70 Blocking Peptide
DF12988-BP
Affbiotech
1mg
EUR 234
Human Exonuclease V (EXO5)
1-CSB-EP863995HU
Cusabio
EUR 456.00
EUR 256.80
EUR 1570.80
EUR 672.00
EUR 1047.60
EUR 314.40
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Human Exonuclease V(EXO5) expressed in E.coli
Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
H-7804.1000
Bachem
1.0mg
EUR 205.2
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net
Tau Peptide (74-102) (Exon 3/Insert 2 Domain)
H-7806.0500
Bachem
0.5mg
EUR 135.6
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net
Tau Peptide (74-102) (Exon 3/Insert 2 Domain)
H-7806.1000
Bachem
1.0mg
EUR 205.2
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net
Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
H-7804.0500
Bachem
0.5mg
EUR 135.6
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net
Exonuclease 1 (EXO1) Antibody
abx232891-100ug
Abbexa
100 ug
EUR 661.2
Rat Exonuclease 1 (EXO1) Protein
20-abx168983
Abbexa
EUR 844.80
EUR 343.20
EUR 2581.20
EUR 994.80
EUR 594.00
100 ug
10 ug
1 mg
200 ug
50 ug
Exonuclease 1 (EXO1) Antibody
20-abx325683
Abbexa
Exonuclease 1 (EXO1) Antibody
20-abx112408
Abbexa
Exonuclease 1 (EXO1) Antibody
abx031761-400ul
Abbexa
400 ul
EUR 627.6
Exonuclease 1 (EXO1) Antibody
abx031761-80l
Abbexa
80 µl
EUR 343.2
Exonuclease V (EXO5) Antibody
abx025735-400ul
Abbexa
400 ul
EUR 627.6
Exonuclease V (EXO5) Antibody
abx025735-80l
Abbexa
80 µl
EUR 343.2
Exonuclease 1 (EXO1) Antibody
20-abx131142
Abbexa
EUR 543.60
EUR 159.60
EUR 1562.40
EUR 744.00
EUR 410.40
100 ug
10 ug
1 mg
200 ug
50 ug
Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.