Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expressed in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.

DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.

Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.

This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.

Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation

Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.

Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.

ExoPure? Mini Chromatography Columns
K1247-10	Biovision	each	EUR 874.8

ExoPure? Mini Chromatography Columns
K1247-20	Biovision	each	EUR 1214.4

ExoPure? Maxi Chromatography Columns
K1248-3	Biovision	each	EUR 1104

ExoPure? Maxi Chromatography Columns
K1248-6	Biovision	each	EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)
K1237-10	Biovision	each	EUR 796.8

ExoPure? Isolation Kit   (Cell Media)
K1237-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-2	Biovision	each	EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-10	Biovision	each	EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-2	Biovision	each	EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-10	Biovision	each	EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-20	Biovision	each	EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-5	Biovision	each	EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
M1007-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
M1008-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)
M1009-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1010-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1011-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1012-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1013-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1014-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1015-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-3	Biovision	each	EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-5	Biovision	each	EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)
M1004-100-T	Biovision	each	EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)
M1005-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)
M1006-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1030-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1030-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1030-3	Biovision	each	EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1031-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1031-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1031-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)
M1039-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)
M1039-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)
M1039-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)
M1039-5	Biovision	each	EUR 796.8

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)
MBS1247989-INQUIRE	MyBiosource	INQUIRE	Ask for price

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)
MBS7014432-002mg	MyBiosource	0.02mg	EUR 2195

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)
MBS7014432-01mg	MyBiosource	0.1mg	EUR 3115

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP)
MBS7014432-5x01mg	MyBiosource	5x0.1mg	EUR 13980

Exophilin 5 (EXPH5) Antibody
abx313705-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody
20-abx313705	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Exophilin 5 (EXPH5) Antibody
abx313705-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody
abx313705-50g	Abbexa	50 µg	EUR 250

Exophilin 5 (EXPH5) Antibody
abx232909-100g	Abbexa	100 µg	EUR 350

Exophilin 5 (EXPH5) Antibody
abx232909-100ug	Abbexa	100 ug	EUR 661.2

Human Exophilin 5 (EXPH5)ELISA Kit
201-12-2684	Shanghai Sunred Biological Technology	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (HRP)
20-abx313706	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-50g	Abbexa	50 µg	EUR 250

Human Exophilin 5 (EXPH5) ELISA Kit
abx387228-96tests	Abbexa	96 tests	EUR 687.5

Mouse Exophilin 5 (EXPH5) ELISA Kit
abx389223-96tests	Abbexa	96 tests	EUR 687.5

Human Exophilin- 5, EXPH5 ELISA KIT
ELI-47267h	Lifescience Market	96 Tests	EUR 988.8

Human Exophilin 5,EXPH5 ELISA KIT
E2683Hu-1096T	Jiaxing Korain Biotech Ltd (BT Labs)	10*96T	EUR 4122

Human Exophilin 5,EXPH5 ELISA KIT
E2683Hu-48wells	Jiaxing Korain Biotech Ltd (BT Labs)	48 wells	EUR 300

Human Exophilin 5,EXPH5 ELISA KIT
E2683Hu-596T	Jiaxing Korain Biotech Ltd (BT Labs)	5*96T	EUR 2061

Human Exophilin 5,EXPH5 ELISA KIT
E2683Hu-96wells	Jiaxing Korain Biotech Ltd (BT Labs)	96 wells	EUR 458

Human Exophilin 5,EXPH5 ELISA KIT
JOT-EK2683Hu	Jotbody	96 wells	Ask for price
Description: Human

Mouse Exophilin- 5, Exph5 ELISA KIT
ELI-26993m	Lifescience Market	96 Tests	EUR 1038

Human Exophilin 5 (EXPH5) ELISA Kit
MBS162932-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3460

Human Exophilin 5 (EXPH5) ELISA Kit
MBS162932-48StripWells	MyBiosource	48-Strip-Wells	EUR 285

Human Exophilin 5 (EXPH5) ELISA Kit
MBS162932-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1750

Human Exophilin 5 (EXPH5) ELISA Kit
MBS162932-96StripWells	MyBiosource	96-Strip-Wells	EUR 425

Human Exophilin 5 (EXPH5) ELISA Kit
MBS9302509-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Exophilin 5 (EXPH5) ELISA Kit
MBS9302509-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Exophilin 5 (EXPH5) ELISA Kit
MBS9302509-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Exophilin 5 (EXPH5) ELISA Kit
MBS9302509-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Illustra Exoprostar 100 RCN - EACH
US78210	Scientific Laboratory Supplies	EACH	EUR 98.55

Illustra Exoprostar 500 RCN - EACH
US78211	Scientific Laboratory Supplies	EACH	EUR 376.65

Illustra Exoprostar 2000 RCN - EACH
US78212	Scientific Laboratory Supplies	EACH	EUR 1347.3

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-48T	Shanghai YL Biotech	48T	Ask for price

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-96T	Shanghai YL Biotech	96T	Ask for price

EXO-Prep for exosome isolation from Urine
HBM-EXP-U25	HansaBioMed	30 ml (25 react)	EUR 234.36

Recombinant Rhizobium meliloti Succinoglycan biosynthesis transport protein exoP (exoP), partial
MBS7060111-INQUIRE	MyBiosource	INQUIRE	Ask for price

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (FITC)
20-abx313707	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-50g	Abbexa	50 µg	EUR 250

Human Exophilin-5, EXPH5 ELISA Kit
MBS9331358-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Exophilin-5, EXPH5 ELISA Kit
MBS9331358-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Exophilin-5, EXPH5 ELISA Kit
MBS9331358-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Exophilin-5, EXPH5 ELISA Kit
MBS9331358-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Mouse Exophilin-5, EXPH5 ELISA Kit
MBS9339734-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Mouse Exophilin-5, EXPH5 ELISA Kit
MBS9339734-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Mouse Exophilin-5, EXPH5 ELISA Kit
MBS9339734-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Mouse Exophilin-5, EXPH5 ELISA Kit
MBS9339734-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (AP)
MBS6416475-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (AP)
MBS6416475-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (PE)
MBS6416485-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (PE)
MBS6416485-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (APC)
MBS6416476-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (APC)
MBS6416476-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (FITC)
MBS6416478-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (FITC)
MBS6416478-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (HRP)
MBS6416479-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (HRP)
MBS6416479-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXO-Prep for exosome isolation from Cell Media
HBM-EXP-C25	HansaBioMed	25 ml (25 react)	EUR 234.36

Illustra ExoPro S 100 Reactions - EACH
US79010	Scientific Laboratory Supplies	EACH	EUR 90.45

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (Biotin)
MBS6416477-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (Biotin)
MBS6416477-5x01mL	MyBiosource	5x0.1mL	EUR 4120

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (Biotin)
20-abx313708	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-50g	Abbexa	50 µg	EUR 250

Human Exophilin 5-EXPH5-ELISA Kit
QY-E04934	Qayee Biotechnology	96T	EUR 400

Human Exophilin 5, EXPH5 GENLISA ELISA
KBH2683	Krishgen	1 x 96 wells	EUR 286

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 405)
MBS6416480-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 405)
MBS6416480-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 490)
MBS6416481-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 490)
MBS6416481-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 550)
MBS6416482-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 550)
MBS6416482-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 650)
MBS6416483-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 650)
MBS6416483-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 750)
MBS6416484-01mL	MyBiosource	0.1mL	EUR 950

EXOC7 (Exocyst Complex Component 7, EX070, EXO70, EXOC1, 2-5-3p, Exo70p, YJL085W) (MaxLight 750)
MBS6416484-5x01mL	MyBiosource	5x0.1mL	EUR 4120

EXO-Prep for exosome isolation from Plasma and serum
HBM-EXP-B5	HansaBioMed	5 ml	EUR 181.44

Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit
EF014853	Lifescience Market	96 Tests	EUR 826.8

Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.