Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expressed in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.

DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.


Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.

This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.

 Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation

Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.

Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.

ExoPure? Mini Chromatography Columns

K1247-10 each
EUR 874.8

ExoPure? Mini Chromatography Columns

K1247-20 each
EUR 1214.4

ExoPure? Maxi Chromatography Columns

K1248-3 each
EUR 1104

ExoPure? Maxi Chromatography Columns

K1248-6 each
EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)

K1237-10 each
EUR 796.8

ExoPure? Isolation Kit   (Cell Media)

K1237-2 each
EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10 each
EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2 each
EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10 each
EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2 each
EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10 each
EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2 each
EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10 each
EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20 each
EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5 each
EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1015-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3 each
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5 each
EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T each
EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3 each
EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5 each
EUR 796.8

Illustra Exoprostar 100 RCN

US78210 EACH
EUR 87.6

Illustra Exoprostar 500 RCN

US78211 EACH
EUR 334.8

Illustra Exoprostar 2000 RCN

US78212 EACH
EUR 1197.6

Exophilin 5 (EXPH5) Antibody

20-abx313705
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody

abx232909-100ug 100 ug
EUR 661.2

Exophilin 5 (EXPH5) Antibody (HRP)

20-abx313706
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Exophilin 5 (EXPH5) ELISA Kit

abx389223-96tests 96 tests
EUR 1093.2

Human Exophilin 5 (EXPH5) ELISA Kit

abx387228-96tests 96 tests
EUR 1093.2

Human Exophilin 5 (EXPH5)ELISA Kit

201-12-2684 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Exophilin- 5, EXPH5 ELISA KIT

ELI-47267h 96 Tests
EUR 988.8

Mouse Exophilin- 5, Exph5 ELISA KIT

ELI-26993m 96 Tests
EUR 1038

Illustra ExoPro S 100 Reactions

US79010 EACH
EUR 80.4

Human Exophilin 5(EXPH5)ELISA Kit

QY-E04934 96T
EUR 433.2

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-48T 48T
EUR 435

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-96T 96T
EUR 562.5

Exophilin 5 (EXPH5) Antibody (FITC)

20-abx313707
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody (Biotin)

20-abx313708
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit

EF014853 96 Tests
EUR 826.8

Exopolyphosphatase (PPX1) Antibody

20-abx300871
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exopolyphosphatase (PPX1) Antibody (HRP)

20-abx300912
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exopolyphosphatase (PPX1) Antibody (FITC)

20-abx300913
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Escherichia coli O6:H1 Exopolyphosphatase (ppx)

1-CSB-EP360285EGX
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli Exopolyphosphatase (ppx)

1-CSB-EP365319ENV
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli O6:H1 Exopolyphosphatase (ppx)

1-CSB-YP360285EGX
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in Yeast

Exopolyphosphatase (PPX1) Antibody (Biotin)

20-abx300914
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody

20-abx334087
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)

20-abx337306
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)

20-abx337307
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)

20-abx337308
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

1-CSB-EP334459SVG
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in E.coli

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

1-CSB-YP334459SVG
  • EUR 814.80
  • EUR 402.00
  • EUR 2606.40
  • EUR 1261.20
  • EUR 1730.40
  • EUR 522.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in Yeast

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)

RPC22737-100ug 100ug
EUR 721.6

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)

RPC22737-1mg 1mg
EUR 2884.7

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)

RPC22737-20ug 20ug
EUR 448.1

Recombinant Escherichia coli Exopolyphosphatase (ppx)

RPC22804-100ug 100ug
EUR 721.6

Recombinant Escherichia coli Exopolyphosphatase (ppx)

RPC22804-1mg 1mg
EUR 2884.7

Recombinant Escherichia coli Exopolyphosphatase (ppx)

RPC22804-20ug 20ug
EUR 448.1

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-10ug

QP7336-ec-10ug 10ug
EUR 391.2

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-1mg

QP7336-ec-1mg 1mg
EUR 2763.6

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-50ug

QP7336-ec-50ug 50ug
EUR 522

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-10ug

QP7169-ec-10ug 10ug
EUR 391.2

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-1mg

QP7169-ec-1mg 1mg
EUR 2763.6

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-50ug

QP7169-ec-50ug 50ug
EUR 522

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-100ug

QP7336-ec-100ug 100ug
EUR 848.4

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-200ug

QP7336-ec-200ug 200ug
EUR 1338

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-500ug

QP7336-ec-500ug 500ug
EUR 1816.8

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-100ug

QP7169-ec-100ug 100ug
EUR 848.4

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-200ug

QP7169-ec-200ug 200ug
EUR 1338

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-500ug

QP7169-ec-500ug 500ug
EUR 1816.8

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

RPC22558-100ug 100ug
EUR 721.6

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

RPC22558-1mg 1mg
EUR 2884.7

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

RPC22558-20ug 20ug
EUR 448.1

Exo70 (Exo70) Antibody

abx232892-100ug 100 ug
EUR 577.2

Exo I 10 U Ul 5000 Units

E70073X EACH
EUR 672

Exo70 Antibody

DF12988 100ul
EUR 280
Description: Human,Mouse,Rat

Exo70 antibody

E39-02892 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Exo70 Antibody

DF12988-100ul 100ul
EUR 280

Exo70 Antibody

DF12988-200ul 200ul
EUR 350

Exo70 antibody

CAF50108-100ug 100ug
EUR 312

Exo70 ELISA KIT|Human

EF009471 96 Tests
EUR 826.8

anti- Exo70 antibody

FNab02892 100µg
EUR 606.3
Description: Antibody raised against Exo70

Exonuclease V / EXO5 / DEM1

F54546-0.08ML 0.08 ml
EUR 140.25
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]

Exonuclease V / EXO5 / DEM1

F54546-0.4ML 0.4 ml
EUR 322.15
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]

Exo1

B6876-10 10 mg
EUR 150
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1

B6876-100 100 mg
EUR 619.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1

B6876-5.1 10 mM (in 1mL DMSO)
EUR 158.4
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1

B6876-50 50 mg
EUR 385.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1

HY-112670 50mg
EUR 308.4

Exo70 Blocking Peptide

DF12988-BP 1mg
EUR 234

Human Exonuclease V (EXO5)

1-CSB-EP863995HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Exonuclease V(EXO5) expressed in E.coli

Tau Peptide (45-73) (Exon 2/Insert 1 Domain)

H-7804.1000 1.0mg
EUR 205.2
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net

Tau Peptide (74-102) (Exon 3/Insert 2 Domain)

H-7806.0500 0.5mg
EUR 135.6
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net

Tau Peptide (74-102) (Exon 3/Insert 2 Domain)

H-7806.1000 1.0mg
EUR 205.2
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net

Tau Peptide (45-73) (Exon 2/Insert 1 Domain)

H-7804.0500 0.5mg
EUR 135.6
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net

Exonuclease 1 (EXO1) Antibody

abx232891-100ug 100 ug
EUR 661.2

Rat Exonuclease 1 (EXO1) Protein

20-abx168983
  • EUR 844.80
  • EUR 343.20
  • EUR 2581.20
  • EUR 994.80
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Exonuclease 1 (EXO1) Antibody

20-abx325683
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Exonuclease 1 (EXO1) Antibody

20-abx112408
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Exonuclease 1 (EXO1) Antibody

abx031761-400ul 400 ul
EUR 627.6

Exonuclease 1 (EXO1) Antibody

abx031761-80l 80 µl
EUR 343.2

Exonuclease V (EXO5) Antibody

abx025735-400ul 400 ul
EUR 627.6

Exonuclease V (EXO5) Antibody

abx025735-80l 80 µl
EUR 343.2

Exonuclease 1 (EXO1) Antibody

20-abx131142
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.