Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expressed in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.

DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.

Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.

This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.

Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation

Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.

Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.

ExoPure? Mini Chromatography Columns
K1247-10	Biovision	each	EUR 874.8

ExoPure? Mini Chromatography Columns
K1247-20	Biovision	each	EUR 1214.4

ExoPure? Maxi Chromatography Columns
K1248-3	Biovision	each	EUR 1104

ExoPure? Maxi Chromatography Columns
K1248-6	Biovision	each	EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)
K1237-10	Biovision	each	EUR 796.8

ExoPure? Isolation Kit   (Cell Media)
K1237-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-2	Biovision	each	EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-10	Biovision	each	EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-2	Biovision	each	EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-10	Biovision	each	EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-20	Biovision	each	EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-5	Biovision	each	EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
M1007-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
M1008-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)
M1009-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1010-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1011-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1012-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1013-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1014-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1015-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-3	Biovision	each	EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-5	Biovision	each	EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)
M1004-100-T	Biovision	each	EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)
M1005-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)
M1006-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1030-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1030-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1030-3	Biovision	each	EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1031-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1031-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1031-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)
M1039-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)
M1039-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)
M1039-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)
M1039-5	Biovision	each	EUR 796.8

Illustra Exoprostar 100 RCN
US78210	Scientific Laboratory Supplies	EACH	EUR 87.6

Illustra Exoprostar 500 RCN
US78211	Scientific Laboratory Supplies	EACH	EUR 334.8

Illustra Exoprostar 2000 RCN
US78212	Scientific Laboratory Supplies	EACH	EUR 1197.6

Exophilin 5 (EXPH5) Antibody
20-abx313705	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exophilin 5 (EXPH5) Antibody
abx232909-100ug	Abbexa	100 ug	EUR 661.2

Exophilin 5 (EXPH5) Antibody (HRP)
20-abx313706	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Mouse Exophilin 5 (EXPH5) ELISA Kit
abx389223-96tests	Abbexa	96 tests	EUR 1093.2

Human Exophilin 5 (EXPH5) ELISA Kit
abx387228-96tests	Abbexa	96 tests	EUR 1093.2

Human Exophilin 5 (EXPH5)ELISA Kit
201-12-2684	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Exophilin- 5, EXPH5 ELISA KIT
ELI-47267h	Lifescience Market	96 Tests	EUR 988.8

Mouse Exophilin- 5, Exph5 ELISA KIT
ELI-26993m	Lifescience Market	96 Tests	EUR 1038

Illustra ExoPro S 100 Reactions
US79010	Scientific Laboratory Supplies	EACH	EUR 80.4

Human Exophilin 5(EXPH5)ELISA Kit
QY-E04934	Qayee Biotechnology	96T	EUR 433.2

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-48T	Shanghai YL Biotech	48T	EUR 435

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-96T	Shanghai YL Biotech	96T	EUR 562.5

Exophilin 5 (EXPH5) Antibody (FITC)
20-abx313707	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exophilin 5 (EXPH5) Antibody (Biotin)
20-abx313708	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit
EF014853	Lifescience Market	96 Tests	EUR 826.8

Exopolyphosphatase (PPX1) Antibody
20-abx300871	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exopolyphosphatase (PPX1) Antibody (HRP)
20-abx300912	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Exopolyphosphatase (PPX1) Antibody (FITC)
20-abx300913	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-EP360285EGX	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli Exopolyphosphatase (ppx)
1-CSB-EP365319ENV	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-YP360285EGX	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in Yeast

Exopolyphosphatase (PPX1) Antibody (Biotin)
20-abx300914	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody
20-abx334087	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
20-abx337306	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
20-abx337307	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
20-abx337308	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
1-CSB-EP334459SVG	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in E.coli

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
1-CSB-YP334459SVG	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in Yeast

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-100ug	Biomatik Corporation	100ug	EUR 721.6

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-1mg	Biomatik Corporation	1mg	EUR 2884.7

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
RPC22737-20ug	Biomatik Corporation	20ug	EUR 448.1

Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-100ug	Biomatik Corporation	100ug	EUR 721.6

Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-1mg	Biomatik Corporation	1mg	EUR 2884.7

Recombinant Escherichia coli Exopolyphosphatase (ppx)
RPC22804-20ug	Biomatik Corporation	20ug	EUR 448.1

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-10ug
QP7336-ec-10ug	EnQuireBio	10ug	EUR 391.2

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-1mg
QP7336-ec-1mg	EnQuireBio	1mg	EUR 2763.6

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-50ug
QP7336-ec-50ug	EnQuireBio	50ug	EUR 522

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-10ug
QP7169-ec-10ug	EnQuireBio	10ug	EUR 391.2

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-1mg
QP7169-ec-1mg	EnQuireBio	1mg	EUR 2763.6

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-50ug
QP7169-ec-50ug	EnQuireBio	50ug	EUR 522

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-100ug
QP7336-ec-100ug	EnQuireBio	100ug	EUR 848.4

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-200ug
QP7336-ec-200ug	EnQuireBio	200ug	EUR 1338

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-500ug
QP7336-ec-500ug	EnQuireBio	500ug	EUR 1816.8

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-100ug
QP7169-ec-100ug	EnQuireBio	100ug	EUR 848.4

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-200ug
QP7169-ec-200ug	EnQuireBio	200ug	EUR 1338

Recombinant S. cerevisiae Exopolyphosphatase Protein, His, E.coli-500ug
QP7169-ec-500ug	EnQuireBio	500ug	EUR 1816.8

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-100ug	Biomatik Corporation	100ug	EUR 721.6

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-1mg	Biomatik Corporation	1mg	EUR 2884.7

Recombinant Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
RPC22558-20ug	Biomatik Corporation	20ug	EUR 448.1

Exo70 (Exo70) Antibody
abx232892-100ug	Abbexa	100 ug	EUR 577.2

Exo I 10 U Ul 5000 Units
E70073X	Scientific Laboratory Supplies	EACH	EUR 672

Exo70 Antibody
DF12988	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse,Rat

Exo70 antibody
E39-02892	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

Exo70 Antibody
DF12988-100ul	Affinity Biosciences	100ul	EUR 280

Exo70 Antibody
DF12988-200ul	Affinity Biosciences	200ul	EUR 350

Exo70 antibody
CAF50108-100ug	Biomatik Corporation	100ug	EUR 312

Exo70 ELISA KIT|Human
EF009471	Lifescience Market	96 Tests	EUR 826.8

anti- Exo70 antibody
FNab02892	FN Test	100µg	EUR 606.3
Description: Antibody raised against Exo70

Exonuclease V / EXO5 / DEM1
F54546-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]

Exonuclease V / EXO5 / DEM1
F54546-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. [UniProt]

Exo1
B6876-10	ApexBio	10 mg	EUR 150
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1
B6876-100	ApexBio	100 mg	EUR 619.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1
B6876-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 158.4
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1
B6876-50	ApexBio	50 mg	EUR 385.2
Description: IC50: about 20 ?M for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.

Exo1
HY-112670	MedChemExpress	50mg	EUR 308.4

Exo70 Blocking Peptide
DF12988-BP	Affbiotech	1mg	EUR 234

Human Exonuclease V (EXO5)
1-CSB-EP863995HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Exonuclease V(EXO5) expressed in E.coli

Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
H-7804.1000	Bachem	1.0mg	EUR 205.2
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net

Tau Peptide (74-102) (Exon 3/Insert 2 Domain)
H-7806.0500	Bachem	0.5mg	EUR 135.6
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net

Tau Peptide (74-102) (Exon 3/Insert 2 Domain)
H-7806.1000	Bachem	1.0mg	EUR 205.2
Description: Sum Formula: C124H198N34O46; CAS# [1322695-34-0] net

Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
H-7804.0500	Bachem	0.5mg	EUR 135.6
Description: Sum Formula: C120H189N31O57; CAS# [2022956-54-1] net

Exonuclease 1 (EXO1) Antibody
abx232891-100ug	Abbexa	100 ug	EUR 661.2

Rat Exonuclease 1 (EXO1) Protein
20-abx168983	Abbexa	EUR 844.80 EUR 343.20 EUR 2581.20 EUR 994.80 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Exonuclease 1 (EXO1) Antibody
20-abx325683	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Exonuclease 1 (EXO1) Antibody
20-abx112408	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Exonuclease 1 (EXO1) Antibody
abx031761-400ul	Abbexa	400 ul	EUR 627.6

Exonuclease 1 (EXO1) Antibody
abx031761-80l	Abbexa	80 µl	EUR 343.2

Exonuclease V (EXO5) Antibody
abx025735-400ul	Abbexa	400 ul	EUR 627.6

Exonuclease V (EXO5) Antibody
abx025735-80l	Abbexa	80 µl	EUR 343.2

Exonuclease 1 (EXO1) Antibody
20-abx131142	Abbexa	EUR 543.60 EUR 159.60 EUR 1562.40 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.