Fatty acid β-oxidation (FAO) is the main bioenergy pathways in human prostate cancer (PCa) and promising new therapies vulnerabilities. Here we demonstrate the therapeutic efficacy of targeting FAO in prostate tumor clinical cultured ex vivo, and identify DECR1, encoding the enzyme rate-limiting for the acid oxidation of polyunsaturated fats (PUFAs), as excited expressed in tissues of PCa and was associated with survival of relapse-free over short. DECR1 is androgen receptor (AR) gene targets of negative-regulated and, therefore, can promote PCa cell survival and resistance to therapy targeting AR.

DECR1 knockdown selectively inhibit β-oxidation of PUFAs, inhibits the proliferation and migration of PCa cells, including treatment-resistant line, and suppressed tumor cell proliferation and metastasis in xenograft mouse models. Mechanical, caused DECR1 targeting cellular accumulation of PUFA, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings involves the oxidation of PUFAs through DECR1 as unexplored aspects of FAO that promotes PCa cell survival.

Reactive oxygen species (ROS) and mitochondria play an important role in regulating platelet function. determining platelet activation drastic changes in redox balance and the metabolism of platelets. Indeed, several signaling pathways have been shown to induce ROS production by NAPDH oxidase (NOX) and mitochondria, after activation of platelets. Platelet-derived ROS, in turn, further increases ROS production and consequent platelet activation, adhesion and recruitment in the loop auto-reinforcing.

This vicious circle results in platelet procoagulant phenotype and apoptosis, both accounting high thrombotic risk in oxidative stress-related illnesses. This review seeks to explain the molecular mechanisms underlying the production of ROS during platelet activation and altered redox balance effect on platelet function, with a focus on the major progress that has been made in redox biology of platelets. Furthermore, given the increased interest in this field, we also describe a method of up-to-date to detect platelets, ROS and bioenergy profile platelets, which have been proposed as potential biomarkers of disease.

Both aerobic glycolysis and mitochondrial respiration necessary for osteoclast differentiation

Excessive bone resorption over bone formation is the root cause of bone loss that leads to osteoporosis fractures. Development of new antiresorptive therapy calls for a holistic understanding of osteoclast differentiation and function.

Although much has been learned about the regulation of the molecular biology of osteoclasts, little is known about the metabolism and bioenergetics requirements during osteoclastogenesis. Here, we report that glucose metabolism through oxidative phosphorylation (OXPHOS) is the dominant bioenergy pathways to support osteoclast differentiation. Meanwhile, increased production of lactate from glucose, which is known as aerobic glycolysis when oxygen is plentiful, it is also important for osteoclastogenesis.

ExoPure? Mini Chromatography Columns
K1247-10	Biovision	each	EUR 874.8

ExoPure? Mini Chromatography Columns
K1247-20	Biovision	each	EUR 1214.4

ExoPure? Maxi Chromatography Columns
K1248-3	Biovision	each	EUR 1104

ExoPure? Maxi Chromatography Columns
K1248-6	Biovision	each	EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)
K1237-10	Biovision	each	EUR 796.8

ExoPure? Isolation Kit   (Cell Media)
K1237-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)
K1241-2	Biovision	each	EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-10	Biovision	each	EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)
K1238-2	Biovision	each	EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-10	Biovision	each	EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)
K1239-2	Biovision	each	EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-25	Biovision	each	EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-50	Biovision	each	EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-10	Biovision	each	EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-20	Biovision	each	EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-5	Biovision	each	EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
M1007-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
M1008-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)
M1009-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1010-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1011-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1012-100-B	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1013-100-T	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1014-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1015-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-3	Biovision	each	EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-5	Biovision	each	EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)
M1004-100-T	Biovision	each	EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)
M1005-100-W	Biovision	each	EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)
M1006-100-B	Biovision	each	EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1030-10	Biovision	each	EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1030-20	Biovision	each	EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1030-3	Biovision	each	EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1031-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1031-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1031-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5	Biovision	each	EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)
M1039-10	Biovision	each	EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)
M1039-20	Biovision	each	EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)
M1039-3	Biovision	each	EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)
M1039-5	Biovision	each	EUR 796.8

Exophilin 5 (EXPH5) Antibody
abx232909-100ug	Abbexa	100 ug	EUR 661.2

Exophilin 5 (EXPH5) Antibody
20-abx313705	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exophilin 5 (EXPH5) Antibody
abx232909-100g	Abbexa	100 µg	EUR 350

Exophilin 5 (EXPH5) Antibody
abx313705-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody
abx313705-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody
abx313705-50g	Abbexa	50 µg	EUR 250

Human Exophilin 5 (EXPH5)ELISA Kit
201-12-2684	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Exophilin 5 (EXPH5) ELISA Kit
abx389223-96tests	Abbexa	96 tests	EUR 1093.2

Human Exophilin 5 (EXPH5) ELISA Kit
abx387228-96tests	Abbexa	96 tests	EUR 1093.2

Exophilin 5 (EXPH5) Antibody (HRP)
20-abx313706	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Human Exophilin- 5, EXPH5 ELISA KIT
ELI-47267h	Lifescience Market	96 Tests	EUR 988.8

Mouse Exophilin- 5, Exph5 ELISA KIT
ELI-26993m	Lifescience Market	96 Tests	EUR 1038

Human Exophilin 5(EXPH5)ELISA Kit
QY-E04934	Qayee Biotechnology	96T	EUR 433.2

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-48T	Shanghai YL Biotech	48T	Ask for price

Human Exophilin 5 (EXPH5)ELISA Kit
YLA3324HU-96T	Shanghai YL Biotech	96T	Ask for price

Illustra Exoprostar 100 RCN - EACH
US78210	Scientific Laboratory Supplies	EACH	EUR 98.55

Illustra Exoprostar 500 RCN - EACH
US78211	Scientific Laboratory Supplies	EACH	EUR 376.65

Illustra Exoprostar 2000 RCN - EACH
US78212	Scientific Laboratory Supplies	EACH	EUR 1347.3

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (HRP)
abx313706-50g	Abbexa	50 µg	EUR 250

EXO-Prep for exosome isolation from Urine
HBM-EXP-U25	HansaBioMed	30 ml (25 react)	EUR 234.36

Exophilin 5 (EXPH5) Antibody (FITC)
20-abx313707	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (FITC)
abx313707-50g	Abbexa	50 µg	EUR 250

Illustra ExoPro S 100 Reactions - EACH
US79010	Scientific Laboratory Supplies	EACH	EUR 90.45

EXO-Prep for exosome isolation from Cell Media
HBM-EXP-C25	HansaBioMed	25 ml (25 react)	EUR 234.36

Exophilin 5 (EXPH5) Antibody (Biotin)
20-abx313708	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-100g	Abbexa	100 µg	EUR 362.5

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-20g	Abbexa	20 µg	EUR 162.5

Exophilin 5 (EXPH5) Antibody (Biotin)
abx313708-50g	Abbexa	50 µg	EUR 250

Human Exophilin 5, EXPH5 GENLISA ELISA
KBH2683	Krishgen	1 x 96 wells	EUR 286

EXO-Prep for exosome isolation from Plasma and serum
HBM-EXP-B5	HansaBioMed	5 ml	EUR 181.44

Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit
EF014853	Lifescience Market	96 Tests	EUR 826.8

EXPH5 (untagged)-Human exophilin 5 (EXPH5)
SC309119	Origene Technologies GmbH	10 µg	Ask for price

EXPH5 (GFP-tagged) - Human exophilin 5 (EXPH5)
RG218060	Origene Technologies GmbH	10 µg	Ask for price

Exopolyphosphatase (PPX1) Antibody
20-abx300871	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exph5 (untagged) - Mouse exophilin 5 (Exph5), (10ug)
MC225085	Origene Technologies GmbH	10 µg	Ask for price

Exopolyphosphatase (PPX1) Antibody
abx300871-100g	Abbexa	100 µg	EUR 362.5

Exopolyphosphatase (PPX1) Antibody
abx300871-20g	Abbexa	20 µg	EUR 162.5

Exopolyphosphatase (PPX1) Antibody
abx300871-50g	Abbexa	50 µg	EUR 250

Exopolyphosphatase (PPX1) Antibody (HRP)
20-abx300912	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exph5 (GFP-tagged) - Mouse exophilin 5 (Exph5), (10ug)
MG218647	Origene Technologies GmbH	10 µg	Ask for price

Exopolyphosphatase (PPX1) Antibody (HRP)
abx300912-100g	Abbexa	100 µg	EUR 362.5

Exopolyphosphatase (PPX1) Antibody (HRP)
abx300912-20g	Abbexa	20 µg	EUR 162.5

Exopolyphosphatase (PPX1) Antibody (HRP)
abx300912-50g	Abbexa	50 µg	EUR 250

Exopolyphosphatase (PPX1) Antibody (FITC)
20-abx300913	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Exph5 (Myc-DDK-tagged) - Mouse exophilin 5 (Exph5)
MR218647	Origene Technologies GmbH	10 µg	Ask for price

EXPH5 (Myc-DDK-tagged)-Human exophilin 5 (EXPH5)
RC218060	Origene Technologies GmbH	10 µg	Ask for price

Exopolyphosphatase (PPX1) Antibody (FITC)
abx300913-100g	Abbexa	100 µg	EUR 362.5

Exopolyphosphatase (PPX1) Antibody (FITC)
abx300913-20g	Abbexa	20 µg	EUR 162.5

Exopolyphosphatase (PPX1) Antibody (FITC)
abx300913-50g	Abbexa	50 µg	EUR 250

Exopolyphosphatase (PPX1) Antibody (Biotin)
20-abx300914	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-YP360285EGX	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in Yeast

Escherichia coli O6:H1 Exopolyphosphatase (ppx)
1-CSB-EP360285EGX	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli Exopolyphosphatase (ppx)
1-CSB-EP365319ENV	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Escherichia coli Exopolyphosphatase(ppx) expressed in E.coli

Exopolyphosphatase (PPX1) Antibody (Biotin)
abx300914-100g	Abbexa	100 µg	EUR 362.5

Exopolyphosphatase (PPX1) Antibody (Biotin)
abx300914-20g	Abbexa	20 µg	EUR 162.5

Exopolyphosphatase (PPX1) Antibody (Biotin)
abx300914-50g	Abbexa	50 µg	EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody
20-abx334087	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody
abx334087-100g	Abbexa	100 µg	EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody
abx334087-20g	Abbexa	20 µg	EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody
abx334087-50g	Abbexa	50 µg	EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
20-abx337306	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
abx337306-100g	Abbexa	100 µg	EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
abx337306-20g	Abbexa	20 µg	EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)
abx337306-50g	Abbexa	50 µg	EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
20-abx337307	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
abx337307-100g	Abbexa	100 µg	EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
abx337307-20g	Abbexa	20 µg	EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)
abx337307-50g	Abbexa	50 µg	EUR 250

Bovine PRUNE1 / Exopolyphosphatase PRUNE1 ELISA Kit
E6149b	EIAab	96T	EUR 900

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
20-abx337308	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 1 mg 200 ug 20 ug 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
abx337308-100g	Abbexa	100 µg	EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
abx337308-20g	Abbexa	20 µg	EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)
abx337308-50g	Abbexa	50 µg	EUR 250

EXPH5 (untagged)-Human exophilin 5 (EXPH5), transcript variant 3
SC325421	Origene Technologies GmbH	10 µg	Ask for price

EXPH5 (untagged)-Human exophilin 5 (EXPH5), transcript variant 2
SC325422	Origene Technologies GmbH	10 µg	Ask for price

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)
1-CSB-YP334459SVG	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in Yeast

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)
CSB-YP360285EGX	Cusabio	6366 mg	Ask for price

Recombinant Escherichia coli Exopolyphosphatase(ppx)
AP76627	SAB	each	Ask for price

Recombinant Escherichia coli Exopolyphosphatase(ppx)
AP74215	SAB	1mg	EUR 2826

Genetic deletion in osteoclast progenitor Glut1 reduce aerobic glycolysis without sacrificing OXPHOS, but nonetheless reduced osteoclast differentiation in vitro. The progenitor Glut1 deficiency leads to osteopetrosis because fewer osteoclasts specialized in female rats. Thus, Glut1-mediated glucose metabolism through the production of lactic and OXPHOS both required for normal osteoclastogenesis.