Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer’s Risk in Female Brain

The decline in brain glucose metabolism is a hallmark of late-onset Alzheimer’s disease (LOAD). a comprehensive understanding of the aging process dynamic metabolism in the brain may provide insights into the window of opportunity to promote healthy brain aging. chronological aging and endocrinological associated with glucose hypometabolism in the brain and the female brain mitochondrial adaptation.

Using a mouse model of recapitulation fundamental feature of human menopausal transition, the results of transcriptomic analysis revealed a specific phase shift in bioenergy systems biology juxtaposed with bioenergy dysregulation of brain aging in midlife women. transcriptomic profile is predictive of the results of unbiased, metabolomics and lipidomic discovery-based analysis, which revealed the dynamic adaptation of the aging of the female brain glucose utilization centric additional fuel source including amino acids, fatty acids, lipid and ketone bodies. Coupling between the brain and the peripheral metabolism system is dynamic and shifting from uncoupled to coupled under metabolic stress. Collectively, these data provide a detailed profile of the whole system transcriptomic and metabolomics underlying bioenergetic function in the brain and its relationship with metabolic response of peripheral.

Mechanically, this data provides insight into the complex dynamics and endocrinological chronological aging of bioenergy in the female brain. Translationally, findings are predictive of initiation prodromal / LOAD preclinical phase for women in middle age and highlights the therapeutic window opportunity to reduce the risk of late-onset Alzheimer’s disease. appropriate regulation and storage of cellular lipid oxidation is indispensable for the maintenance of cellular energy homeostasis and health. Mitochondrial function has proven to be a major determinant of functional lipid storage and oxidation, which is of particular interest to the adipose tissue, because it is the primary site of storage triacylglyceride in lipid droplets (LDs).

 Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer's Risk in Female Brain
Midlife Chronological and Endocrinological Transitions in Brain Metabolism: System Biology Basis for Increased Alzheimer’s Risk in Female Brain

Dependent mitochondrial uncoupling protein signaling in plant bioenergetics and stress response

Biological function of mitochondrial uncoupling protein crops (pUCPs) has been a matter of considerable controversy. For example, PUCP capacity to uncouple respiration from ATP synthesis in vivo was never fully recognized, in contrast to the role of mammalian UCP1 (mUCP1) in uncoupling of respiration-mediated thermogenesis.

Interestingly, both pUCPs and mUCPs has been associated with the stress response and metabolic disorders. Some of the central questions that remain are how pUCPs and mUCPs comparing the biochemical, molecular and cell biology structure under physiological conditions and metabolic disturbed. This review took advantage of the large amount of data available for mUCPs to review the biochemical properties, 3D structural model and the physiological role pUCPs potential for crop development and response to stress. Biochemical properties and structure pUCPs reviewed in light of recent findings that pUCPs catalyze metabolite transport across the inner mitochondrial membrane and mUCP2 protein structures solved.

ExoPure? Mini Chromatography Columns

K1247-10 each
EUR 874.8

ExoPure? Mini Chromatography Columns

K1247-20 each
EUR 1214.4

ExoPure? Maxi Chromatography Columns

K1248-3 each
EUR 1104

ExoPure? Maxi Chromatography Columns

K1248-6 each
EUR 1690.8

ExoPure? Isolation Kit   (Cell Media)

K1237-10 each
EUR 796.8

ExoPure? Isolation Kit   (Cell Media)

K1237-2 each
EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10 each
EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2 each
EUR 483.6

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10 each
EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2 each
EUR 470.4

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-10 each
EUR 901.2

ExoPure? Isolation Kit   (Stem Cell Media)

K1239-2 each
EUR 510

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50 each
EUR 1083.6

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10 each
EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20 each
EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5 each
EUR 633.6

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1015-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3 each
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5 each
EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T each
EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B each
EUR 888

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3 each
EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5 each
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5 each
EUR 796.8

Exophilin 5 (EXPH5) Antibody

abx232909-100ug 100 ug
EUR 661.2

Exophilin 5 (EXPH5) Antibody

20-abx313705
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody

abx232909-100g 100 µg
EUR 350

Exophilin 5 (EXPH5) Antibody

abx313705-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody

abx313705-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody

abx313705-50g 50 µg
EUR 250

Human Exophilin 5 (EXPH5)ELISA Kit

201-12-2684 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Exophilin 5 (EXPH5) ELISA Kit

abx389223-96tests 96 tests
EUR 1093.2

Human Exophilin 5 (EXPH5) ELISA Kit

abx387228-96tests 96 tests
EUR 1093.2

Exophilin 5 (EXPH5) Antibody (HRP)

20-abx313706
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Exophilin- 5, EXPH5 ELISA KIT

ELI-47267h 96 Tests
EUR 988.8

Mouse Exophilin- 5, Exph5 ELISA KIT

ELI-26993m 96 Tests
EUR 1038

Human Exophilin 5(EXPH5)ELISA Kit

QY-E04934 96T
EUR 433.2

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-48T 48T Ask for price

Human Exophilin 5 (EXPH5)ELISA Kit

YLA3324HU-96T 96T Ask for price

Illustra Exoprostar 100 RCN - EACH

US78210 EACH
EUR 98.55

Illustra Exoprostar 500 RCN - EACH

US78211 EACH
EUR 376.65

Illustra Exoprostar 2000 RCN - EACH

US78212 EACH
EUR 1347.3

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (HRP)

abx313706-50g 50 µg
EUR 250

EXO-Prep for exosome isolation from Urine

HBM-EXP-U25 30 ml (25 react)
EUR 234.36

Exophilin 5 (EXPH5) Antibody (FITC)

20-abx313707
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (FITC)

abx313707-50g 50 µg
EUR 250

Illustra ExoPro S 100 Reactions - EACH

US79010 EACH
EUR 90.45

EXO-Prep for exosome isolation from Cell Media

HBM-EXP-C25 25 ml (25 react)
EUR 234.36

Exophilin 5 (EXPH5) Antibody (Biotin)

20-abx313708
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-100g 100 µg
EUR 362.5

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-20g 20 µg
EUR 162.5

Exophilin 5 (EXPH5) Antibody (Biotin)

abx313708-50g 50 µg
EUR 250

Human Exophilin 5, EXPH5 GENLISA ELISA

KBH2683 1 x 96 wells
EUR 286

EXO-Prep for exosome isolation from Plasma and serum

HBM-EXP-B5 5 ml
EUR 181.44

Exph5 ELISA Kit| Mouse Exophilin-5 ELISA Kit

EF014853 96 Tests
EUR 826.8

EXPH5 (untagged)-Human exophilin 5 (EXPH5)

SC309119 10 µg Ask for price

EXPH5 (GFP-tagged) - Human exophilin 5 (EXPH5)

RG218060 10 µg Ask for price

Exopolyphosphatase (PPX1) Antibody

20-abx300871
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exph5 (untagged) - Mouse exophilin 5 (Exph5), (10ug)

MC225085 10 µg Ask for price

Exopolyphosphatase (PPX1) Antibody

abx300871-100g 100 µg
EUR 362.5

Exopolyphosphatase (PPX1) Antibody

abx300871-20g 20 µg
EUR 162.5

Exopolyphosphatase (PPX1) Antibody

abx300871-50g 50 µg
EUR 250

Exopolyphosphatase (PPX1) Antibody (HRP)

20-abx300912
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exph5 (GFP-tagged) - Mouse exophilin 5 (Exph5), (10ug)

MG218647 10 µg Ask for price

Exopolyphosphatase (PPX1) Antibody (HRP)

abx300912-100g 100 µg
EUR 362.5

Exopolyphosphatase (PPX1) Antibody (HRP)

abx300912-20g 20 µg
EUR 162.5

Exopolyphosphatase (PPX1) Antibody (HRP)

abx300912-50g 50 µg
EUR 250

Exopolyphosphatase (PPX1) Antibody (FITC)

20-abx300913
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Exph5 (Myc-DDK-tagged) - Mouse exophilin 5 (Exph5)

MR218647 10 µg Ask for price

EXPH5 (Myc-DDK-tagged)-Human exophilin 5 (EXPH5)

RC218060 10 µg Ask for price

Exopolyphosphatase (PPX1) Antibody (FITC)

abx300913-100g 100 µg
EUR 362.5

Exopolyphosphatase (PPX1) Antibody (FITC)

abx300913-20g 20 µg
EUR 162.5

Exopolyphosphatase (PPX1) Antibody (FITC)

abx300913-50g 50 µg
EUR 250

Exopolyphosphatase (PPX1) Antibody (Biotin)

20-abx300914
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Escherichia coli O6:H1 Exopolyphosphatase (ppx)

1-CSB-YP360285EGX
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in Yeast

Escherichia coli O6:H1 Exopolyphosphatase (ppx)

1-CSB-EP360285EGX
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli O6:H1 Exopolyphosphatase(ppx) expressed in E.coli

Escherichia coli Exopolyphosphatase (ppx)

1-CSB-EP365319ENV
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Escherichia coli Exopolyphosphatase(ppx) expressed in E.coli

Exopolyphosphatase (PPX1) Antibody (Biotin)

abx300914-100g 100 µg
EUR 362.5

Exopolyphosphatase (PPX1) Antibody (Biotin)

abx300914-20g 20 µg
EUR 162.5

Exopolyphosphatase (PPX1) Antibody (Biotin)

abx300914-50g 50 µg
EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody

20-abx334087
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody

abx334087-100g 100 µg
EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody

abx334087-20g 20 µg
EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody

abx334087-50g 50 µg
EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)

20-abx337306
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)

abx337306-100g 100 µg
EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)

abx337306-20g 20 µg
EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (HRP)

abx337306-50g 50 µg
EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)

20-abx337307
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)

abx337307-100g 100 µg
EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)

abx337307-20g 20 µg
EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (FITC)

abx337307-50g 50 µg
EUR 250

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)

20-abx337308
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)

abx337308-100g 100 µg
EUR 362.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)

abx337308-20g 20 µg
EUR 162.5

Prune Exopolyphosphatase 1 (PRUNE1) Antibody (Biotin)

abx337308-50g 50 µg
EUR 250

EXPH5 (untagged)-Human exophilin 5 (EXPH5), transcript variant 3

SC325421 10 µg Ask for price

EXPH5 (untagged)-Human exophilin 5 (EXPH5), transcript variant 2

SC325422 10 µg Ask for price

Saccharomyces cerevisiae Exopolyphosphatase (PPX1)

1-CSB-YP334459SVG
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Saccharomyces cerevisiae Exopolyphosphatase(PPX1) expressed in Yeast

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)

CSB-YP360285EGX 6366 mg Ask for price

Recombinant Escherichia coli Exopolyphosphatase(ppx)

AP76627 each Ask for price

Recombinant Escherichia coli Exopolyphosphatase(ppx)

AP74215 1mg
EUR 2826

Recombinant Escherichia coli Exopolyphosphatase(ppx)

AP74401 1mg
EUR 2826

Recombinant Escherichia coli O6:H1 Exopolyphosphatase (ppx)

CSB-EP360285EGX 3329 mg Ask for price

Recombinant Escherichia coli Exopolyphosphatase (ppx)

CSB-EP365319ENV 3452 mg Ask for price

In addition, regulatory and transcriptional co-expression network UCP orthologues across species analyzed, taking advantage of publicly available datasets curated experimental. Taking these together, the biological role pUCPs analyzed in the context of their potential role in thermogenesis, ROS production, cell signaling and the regulation of cellular bioenergetics plants. Finally, pUCPs biological functions discussed in the context of their potential role in protecting against environmental stress.