Alzheimer’s disease (AD) is the leading cause of dementia. So far, 99.6% of the clinical trials, including those targeting the energy metabolism, have failed to mobilize disease-modifying properties. altered mitochondrial function and disorders of the brain bioenergy systems have long-documented as early events during the development of AD pathology.
The latest progress: While therapeutic approaches that directly promote mitochondrial bioenergetic machine or eliminating reactive oxygen species exhibited limited translatability, emerging strategies targeting non-energetic aspects of mitochondrial provide a new therapeutic target with the potential to modify the risk of AD and development. Growing evidence also reveals an important relationship between mitochondrial phenotype and neuroinflammation via cells.Herein glial metabolic reprogramming, we summarize the main class of mitochondrial-based therapeutic strategies AD. Moreover, the difference in their success when translated from preclinical models to clinical trials aimed. key factors that distinguish the response to the intervention of bioenergy, including sex, APOE genotype and cellular diversity in the brain, which discussed.
We proposes that the future development of AD mitochondrial targeted therapy should consider the interaction between bioenergetics and mechanisms of other diseases that may require specific types of targeting cell- to distinguish between neurons and cells of non-neural. In addition, a successful strategy will likely include stratification by metabolic phenotype that varies by gender and genetic risk profile and dynamic change throughout the course of the disease. As the network expands in intracellular mitochondria integration and systems biology level, intended- votes, either, compared to unintended consequences, bad, will be required to achieve the therapeutic potential of mitochondria.
Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.
Mitochondrial dysfunction in metabolic disorders associated with age.
Aging is a natural biological processes within an organism that is characterized by bioenergetics and downs of life. Mitochondria are important for cellular bioenergetics and thus an important contributor to age-related damage energetics.
In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis makes this organelle major cellular components that dictate the fate of cells. To maintain the quantity and quality, mitochondria undergo several processes such as fission, fusion and mitophagy to remove or replace the faulty mitochondria. While the machine is properly protected bioenergetics, functional decline associated with age and metabolic diseases associated with age is largely the result of a failure in the protective mechanism.
In addition, the byproducts of metabolism such as reactive oxygen species are also helpful in this damaging path. Mitochondrial dysfunction is always considered to be associated with the disease. In addition, studies in recent years have shown that aging contributes to the decay of mitochondrial health by promoting the imbalance in the mitochondrial pathway-arranged keys. Thus, it is important to understand the nexus of mitochondrial dysfunction and age-related diseases. This review focuses on the various aspects of mitochondrial biology and status on the basis of aging and metabolic diseases associated with age. This article is protected by copyright. All rights reserved.
Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome)
P100EZ
101Bio
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Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample
P100EZ-sample
101Bio
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ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-10
Biovision
each
EUR 1005.6
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-20
Biovision
each
EUR 1546.8
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-3
Biovision
each
EUR 523.2
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)
M1038-5
Biovision
each
EUR 796.8
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)
M1004-100-T
Biovision
each
EUR 1136.4
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)
M1005-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)
M1006-100-B
Biovision
each
EUR 888
Exosome Isolation Kit
E601E001
EnoGene
20 tests
EUR 2500
Exosome Isolation kit (for serum & plasma)
P101
101Bio
-
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Exosome Isolation kit (for serum & plasma)
P101L
101Bio
-
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Exosome Isolation kit (for serum & plasma)
P101S
101Bio
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Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)
P101NGS
101Bio
-
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ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)
M1039-10
Biovision
each
EUR 1005.6
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)
M1039-20
Biovision
each
EUR 1546.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)
M1039-3
Biovision
each
EUR 523.2
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)
M1039-5
Biovision
each
EUR 796.8
Exosome Isolation kit (for cell culture media)
P100
101Bio
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Exosome Isolation kit (for cell culture media)
P100L
101Bio
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Exosome Isolation kit (for cell culture media)
P100S
101Bio
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Exosome Isolation kit (for stem cell culture media)
P107S
101Bio
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Exosome Isolation kit (for stem cell culture media)
P107
101Bio
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GPC1 Capture Exosome Isolation Kit
E601E004
EnoGene
20 tests
EUR 2500
CD63 Capture Exosome Isolation Kit
E601E005
EnoGene
20 tests
EUR 2500
CD81 Capture Exosome Isolation Kit
E601E006
EnoGene
20 tests
EUR 2500
Exosome Isolation kit (forHuman Body Fluid)
P121
101Bio
-
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Exosome Isolation kit (forHuman Body Fluid)
P121L
101Bio
-
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Exosome Isolation kit (forHuman Body Fluid)
P121S
101Bio
-
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Breast cancer Exosome Isolation Kit
E601E002
EnoGene
20 tests
EUR 2500
EPCAM Capture Exosome Isolation Kit
E601E003
EnoGene
20 tests
EUR 2500
HSP70 Capture Exosome Isolation Kit
E601E007
EnoGene
20 tests
EUR 2500
Custom cell exosome isolation
S101
101Bio
-
EUR 700
Disease cell exosome isolation
S102
101Bio
-
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ExoPure? Isolation Kit (Urine)
K1240-10
Biovision
each
EUR 836.4
ExoPure? Isolation Kit (Urine)
K1240-2
Biovision
each
EUR 483.6
Easy-Exo Saliva Exosome Isolation Kit, 95% pure
P530
101Bio
-
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Easy-Exo Saliva Exosome Isolation Kit, 95% pure
P530S
101Bio
-
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Urine DNA Isolation Kit
K5011150
Biochain
1 kit
EUR 237
ExoQuick-LP for lipoprotein pre-clear & exosome isolation
EXOLP5A-1
SBI
5 reactions
EUR 473
VEX Exosome Isolation Reagent (from serum)
R602
Vazyme
10 ml
EUR 769.2
XCF COMPLETE Exosome and cfDNA Isolation Kit (for Serum and Plasma)
XCF100A-1
SBI
20 rxn
EUR 583
VEX Exosome Isolation Reagent (from plasma)
R603
Vazyme
10 ml
EUR 769.2
Reagent for Total Exosome Isolation (Culture Media Supplement)
EIR-02
Creative Biolabs
50 ml
EUR 2485.2
Description: This product is used for isolating exosomes from culture media supplement based on chemical precipitation isolation method.
ExoQuick Exosome Isolation and RNA Purification kit (for Serum and Plasma)
EQ806A-1
SBI
20 preps
EUR 493
FitAmp Urine DNA Isolation Kit
P-1017
EpiGentek
EUR 474.12
EUR 171.60
EUR 292.60
100 Samples
50 Samples
100 Samples
ExoQuick Exosome Isolation and RNA Purification kit (for Tissue Culture Media)
EQ806TC-1
SBI
10 preps
EUR 493
ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-25
Biovision
each
EUR 992.4
ExoPure? Reagent (Overall Exosome Isolation, cell media)
M1002-50
Biovision
each
EUR 1083.6
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)
P101EZ
101Bio
-
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VEX Exosome Isolation Reagent (from cell culture media)
R601
Vazyme
50 ml
EUR 706.8
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-10
Biovision
each
EUR 796.8
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-20
Biovision
each
EUR 1260
ExoPure? Reagent (Overall Exosome Isolation, biological fluids)
M1001-5
Biovision
each
EUR 633.6
Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample
P101EZ--sample
101Bio
-
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ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)
EXOCG50A-1
SBI
50 ml
EUR 1106
TumorExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)
M1016-100-T
Biovision
each
EUR 874.8
TumorExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)
M1017-100-W
Biovision
each
EUR 888
TumorExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)
M1018-100-B
Biovision
each
EUR 888
GlialExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)
M1022-100-T
Biovision
each
EUR 888
GlialExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)
M1023-100-W
Biovision
each
EUR 888
GlialExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)
M1024-100-B
Biovision
each
EUR 888
NeuralExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)
M1019-100-T
Biovision
each
EUR 907.2
NeuralExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)
M1020-100-W
Biovision
each
EUR 888
NeuralExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)
M1021-100-B
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)
M1007-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)
M1008-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)
M1009-100-B
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1010-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1011-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1012-100-B
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)
M1013-100-T
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)
M1014-100-W
Biovision
each
EUR 888
ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)
M1015-100-B
Biovision
each
EUR 888
Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)
M1025-100-T
Biovision
each
EUR 888
Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)
M1026-100-W
Biovision
each
EUR 888
Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)
M1027-100-B
Biovision
each
EUR 888
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1030-10
Biovision
each
EUR 1005.6
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1030-20
Biovision
each
EUR 1546.8
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1030-3
Biovision
each
EUR 529.2
ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1030-5
Biovision
each
EUR 796.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)
M1031-10
Biovision
each
EUR 1005.6
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)
M1031-20
Biovision
each
EUR 1546.8
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)
M1031-3
Biovision
each
EUR 523.2
ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)
M1031-5
Biovision
each
EUR 796.8
XCF Exosomal DNA Isolation Kit
XCF200A-1
SBI
20 rxn
EUR 328
TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)
M1032-10
Biovision
each
EUR 1057.2
TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)
M1032-20
Biovision
each
EUR 1618.8
TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)
M1032-3
Biovision
each
EUR 523.2
TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)
M1032-5
Biovision
each
EUR 796.8
TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)
M1033-10
Biovision
each
EUR 1057.2
TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)
M1033-20
Biovision
each
EUR 1618.8
TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)
M1033-3
Biovision
each
EUR 523.2
TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)
M1033-5
Biovision
each
EUR 796.8
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)
M1034-10
Biovision
each
EUR 1005.6
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)
M1034-20
Biovision
each
EUR 1495.2
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)
M1034-3
Biovision
each
EUR 398.4
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)
M1034-5
Biovision
each
EUR 777.6
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)
M1035-10
Biovision
each
EUR 1005.6
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)
M1035-20
Biovision
each
EUR 1495.2
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)
M1035-3
Biovision
each
EUR 516
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)
M1035-5
Biovision
each
EUR 777.6
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)
M1036-10
Biovision
each
EUR 1005.6
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)
M1036-20
Biovision
each
EUR 1546.8
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)
M1036-3
Biovision
each
EUR 516
MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)
M1036-5
Biovision
each
EUR 777.6
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)
M1037-10
Biovision
each
EUR 1005.6
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)
M1037-20
Biovision
each
EUR 1546.8
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)
M1037-3
Biovision
each
EUR 516
MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)
M1037-5
Biovision
each
EUR 777.6
Exo-Urine EV Isolation Kit
EXOU100A-1
SBI
2 x 5 reactions
EUR 490
Fluorescent Exosome Standard (Urine )
ESF-15
Creative Biolabs
100 µg
EUR 2067.6
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.
ExoFACS? Kit for Urine Exosomes
K1235-20
Biovision
each
EUR 973.2
Exosome Purification and Detection Kit (Urine)
abx290027-25tests
Abbexa
25 tests
EUR 777.6
ExoStd? Urine Fluorescent Exosome Standard
M1075-100
Biovision
each
EUR 907.2
Lyophilized Exosome Standard (Human Urine)
ESL-29
Creative Biolabs
30 µgx2 vials
EUR 1620
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.
ExoQuick ULTRA EV Isolation Kit for Serum and Plasma
EQULTRA-20A-1
SBI
20 reactions
EUR 941
Mammalian Mitochondria Isolation Kit for Tissue
abx098857-50rxns
Abbexa
50 rxns
EUR 493.2
ExoPure? Isolation Kit (Cell Media)
K1237-10
Biovision
each
EUR 796.8
ExoPure? Isolation Kit (Cell Media)
K1237-2
Biovision
each
EUR 470.4
ExoPure? Isolation Kit (Bio Fluids)
K1241-10
Biovision
each
EUR 836.4
ExoPure? Isolation Kit (Bio Fluids)
K1241-2
Biovision
each
EUR 483.6
ExoQuick-TC ULTRA EV Isolation Kit for Tissue Culture Media
EQULTRA-20TC-1
SBI
20 reactions
EUR 518
miRNA Isolation Kit
FAMIK--001
Favorgen
Rxns: 100
EUR 398.4
Description: Contents of the kit:
Rxns :100Lysis
Buffer-10 ml
Acid-Phenol-10 ml
RNA Column and Collection Tube-100 sets
Wash Buffer-10 ml
Release Buffer-0.5 ml
miRNA Isolation Kit
FAMIK--002
Favorgen
Rxns: 50
EUR 267.6
ExoPure? Isolation Kit (Serum, Plasma)
K1238-10
Biovision
each
EUR 836.4
ExoPure? Isolation Kit (Serum, Plasma)
K1238-2
Biovision
each
EUR 470.4
MicroRNA Isolation Kit
KS341025
Biochain
1 kit
EUR 247
Endosome Isolation Kit
P528
101Bio
-
Ask for price
Microsome Isolation Kit
K249-50
Biovision
each
EUR 633.6
ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 2 vials)
M1044-2
Biovision
each
EUR 718.8
ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)
M1044-4
Biovision
each
EUR 1090.8
ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials)
M1044-6
Biovision
each
EUR 1546.8
Which form a biological membrane lipids tend to forget molecular cell biology. Lack of data on important entities may reflect the difficulty of learning and understanding of their biological role, rather than reveal the lack of importance.