Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Alzheimer’s disease (AD) is the leading cause of dementia. So far, 99.6% of the clinical trials, including those targeting the energy metabolism, have failed to mobilize disease-modifying properties. altered mitochondrial function and disorders of the brain bioenergy systems have long-documented as early events during the development of AD pathology.

The latest progress: While therapeutic approaches that directly promote mitochondrial bioenergetic machine or eliminating reactive oxygen species exhibited limited translatability, emerging strategies targeting non-energetic aspects of mitochondrial provide a new therapeutic target with the potential to modify the risk of AD and development. Growing evidence also reveals an important relationship between mitochondrial phenotype and neuroinflammation via cells.Herein glial metabolic reprogramming, we summarize the main class of mitochondrial-based therapeutic strategies AD. Moreover, the difference in their success when translated from preclinical models to clinical trials aimed. key factors that distinguish the response to the intervention of bioenergy, including sex, APOE genotype and cellular diversity in the brain, which discussed.

We proposes that the future development of AD mitochondrial targeted therapy should consider the interaction between bioenergetics and mechanisms of other diseases that may require specific types of targeting cell- to distinguish between neurons and cells of non-neural. In addition, a successful strategy will likely include stratification by metabolic phenotype that varies by gender and genetic risk profile and dynamic change throughout the course of the disease. As the network expands in intracellular mitochondria integration and systems biology level, intended- votes, either, compared to unintended consequences, bad, will be required to achieve the therapeutic potential of mitochondria.

 Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential.
Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Mitochondrial dysfunction in metabolic disorders associated with age.

Aging is a natural biological processes within an organism that is characterized by bioenergetics and downs of life. Mitochondria are important for cellular bioenergetics and thus an important contributor to age-related damage energetics.

In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis makes this organelle major cellular components that dictate the fate of cells. To maintain the quantity and quality, mitochondria undergo several processes such as fission, fusion and mitophagy to remove or replace the faulty mitochondria. While the machine is properly protected bioenergetics, functional decline associated with age and metabolic diseases associated with age is largely the result of a failure in the protective mechanism.

In addition, the byproducts of metabolism such as reactive oxygen species are also helpful in this damaging path. Mitochondrial dysfunction is always considered to be associated with the disease. In addition, studies in recent years have shown that aging contributes to the decay of mitochondrial health by promoting the imbalance in the mitochondrial pathway-arranged keys. Thus, it is important to understand the nexus of mitochondrial dysfunction and age-related diseases. This review focuses on the various aspects of mitochondrial biology and status on the basis of aging and metabolic diseases associated with age. This article is protected by copyright. All rights reserved.

ExoPure? Isolation Kit   (Urine)

K1240-10
EUR 836.4

ExoPure? Isolation Kit   (Urine)

K1240-2
EUR 483.6

Urine DNA Isolation Kit

K5011150 1 kit
EUR 307.2

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T
EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B
EUR 888

Exosome Isolation kit (for serum & plasma)

P101 - Ask for price

Exosome Isolation kit (for serum & plasma)

P101L - Ask for price

Exosome Isolation kit (for serum & plasma)

P101S - Ask for price

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)

P101NGS - Ask for price

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 661.2

FitAmp Urine DNA Isolation Kit 

P-1017
  • EUR 474.12
  • EUR 171.60
  • EUR 292.60
  • 100 Samples
  • 50 Samples
  • 100 Samples

FitAmp Urine DNA Isolation Kit 

P-1017-050 50 Samples
EUR 171.6

FitAmp Urine DNA Isolation Kit 

P-1017-100 100 Samples
EUR 292.6

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome)

P100EZ - Ask for price

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5
EUR 796.8

Exosome Isolation kit (for cell culture media)

P100 - Ask for price

Exosome Isolation kit (for cell culture media)

P100L - Ask for price

Exosome Isolation kit (for cell culture media)

P100S - Ask for price

Fluorescent Exosome Standard (Urine )

ESF-15 100 µg
EUR 2067.6
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample

P100EZ-sample - Ask for price

Exosome Isolation kit (for stem cell culture media)

P107 - Ask for price

Exosome Isolation kit (for stem cell culture media)

P107S - Ask for price

Exosome Purification and Detection Kit (Urine)

abx290027-25tests 25 tests
EUR 777.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5
EUR 796.8

ExoStd? Urine Fluorescent Exosome Standard

M1075-100
EUR 907.2

Lyophilized Exosome Standard (Human Urine)

ESL-29 30 µgx2 vials
EUR 1620
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

Exosome Isolation kit (forHuman Body Fluid)

P121 - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121L - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121S - Ask for price

Reagent for Total Exosome Isolation (Culture Media Supplement)

EIR-02 50 ml
EUR 2485.2
Description: This product is used for isolating exosomes from culture media supplement based on chemical precipitation isolation method.

ExoQuick-LP for lipoprotein pre-clear & exosome isolation

EXOLP5A-1 5 reactions
EUR 639.6

VEX Exosome Isolation Reagent (from serum)

R602 10 ml
EUR 769.2

VEX Exosome Isolation Reagent (from plasma)

R603 10 ml
EUR 769.2

ExoQuick Exosome Isolation and RNA Purification kit (for Serum and Plasma)

EQ806A-1 20 preps
EUR 664.8

ExoQuick Exosome Isolation and RNA Purification kit (for Tissue Culture Media)

EQ806TC-1 10 preps
EUR 664.8

XCF COMPLETE Exosome and cfDNA Isolation Kit (for Serum and Plasma)

XCF100A-1 20 rxn
EUR 776.4

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530 - Ask for price

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530S - Ask for price

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10
EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20
EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5
EUR 633.6

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50
EUR 1083.6

TumorExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1016-100-T
EUR 874.8

TumorExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1017-100-W
EUR 888

TumorExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1018-100-B
EUR 888

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1019-100-T
EUR 907.2

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1020-100-W
EUR 888

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1021-100-B
EUR 888

GlialExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1022-100-T
EUR 888

GlialExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1023-100-W
EUR 888

GlialExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1024-100-B
EUR 888

ExoFACS? Kit for Urine Exosomes

K1235-20
EUR 973.2

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)

P101EZ - Ask for price

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1015-100-B
EUR 888

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1025-100-T
EUR 888

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1026-100-W
EUR 888

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1027-100-B
EUR 888

VEX Exosome Isolation Reagent (from cell culture media)

R601 50 ml
EUR 706.8

ExoQuant? Overall Exosome Capture and Quantification Assay Kit (Human Urine, Luminometric)

K1207-100
EUR 1161.6

ExoQuant? Overall Exosome Capture and Quantification Assay Kit (Human Urine, Colorimetric)

K1202-100
EUR 1161.6

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample

P101EZ--sample - Ask for price

ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)

EXOCG50A-1 50 ml
EUR 1417.2

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 2 vials)

M1044-2
EUR 718.8

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials)

M1044-6
EUR 1546.8

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 2 vials)

M1045-2
EUR 848.4

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4
EUR 1364.4

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 6 vials)

M1045-6
EUR 1886.4

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 493.2

ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome)

P402 - Ask for price

ExoDNAUC? Circulating and Exosome-associated DNA Extraction Kit (Urine/Cell Media, 20 reactions)

K1231-20
EUR 861.6

ExoDNAUC? Circulating and Exosome-associated DNA Extraction Kit (Urine/Cell Media, 40 reactions)

K1231-40
EUR 1273.2

Mammalian Mitochondria Isolation Kit for Cultured Cells

20-abx098856
  • EUR 126.00
  • EUR 493.20
  • 2 rxns
  • 50 rxns

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3
EUR 529.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5
EUR 796.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5
EUR 796.8

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1032-10
EUR 1057.2

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1032-20
EUR 1618.8

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 523.2

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1032-5
EUR 796.8

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1033-10
EUR 1057.2

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1033-20
EUR 1618.8

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 523.2

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1033-5
EUR 796.8

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1034-10
EUR 1005.6

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1034-20
EUR 1495.2

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3
EUR 398.4

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1034-5
EUR 777.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1035-10
EUR 1005.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1035-20
EUR 1495.2

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3
EUR 516

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1035-5
EUR 777.6

Mitochondria Isolation Kit

AR0156 1 kit
EUR 127.2

MicroRNA Isolation Kit

KS341025 1 kit
EUR 307.2
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

miRNA Isolation Kit

FAMIK--001 Rxns: 100
EUR 398.4
Description: Contents of the kit:
  • Rxns:100Lysis
  • Buffer-10 ml
  • Acid-Phenol-10 ml
  • RNA Column and Collection Tube-100 sets
  • Wash Buffer-10 ml
  • Release Buffer-0.5 ml

miRNA Isolation Kit

FAMIK--002 Rxns: 50
EUR 267.6

Preadipocyte Isolation Kit

K583-5
EUR 639.6

Microsome Isolation Kit

K249-50
EUR 633.6

Endosome Isolation Kit

P528 - Ask for price

Rna Isolation Kit

11828665001 EACH
EUR 330.6

ExoStep Urine

ExoS-25-U9 25 test
EUR 660.6

LH (Urine) ELISA Kit

DEIA2231 96T
EUR 670.8
Description: The LH (Urine) ELISA is an enzyme immunoassay for the quantitative in vitro diagnostic measurement of LH in urine. This test is used to detect the midcycle LH surge in urine, which is an aid in predicting the time of ovulation.

Urine Creatinine Detection Kit

SKT-200-192 2 plates of 96 wells
EUR 410.4
Description: Direct Detection kit used for quantitative measuring creatinine in Urine samples from Human, Monkey, Dog, Rat

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1036-10
EUR 1005.6

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1036-20
EUR 1546.8

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3
EUR 516

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1036-5
EUR 777.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1037-10
EUR 1005.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1037-20
EUR 1546.8

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3
EUR 516

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1037-5
EUR 777.6

Mitochondria Isolation Kit for Tissue and Cultured Cells

KC010100 1 kit
EUR 384
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Mammalian Mitochondria Isolation Kit For Tissue & Cultured Cells

K288-50
EUR 502.8


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