Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Alzheimer’s disease (AD) is the leading cause of dementia. So far, 99.6% of the clinical trials, including those targeting the energy metabolism, have failed to mobilize disease-modifying properties. altered mitochondrial function and disorders of the brain bioenergy systems have long-documented as early events during the development of AD pathology.

The latest progress: While therapeutic approaches that directly promote mitochondrial bioenergetic machine or eliminating reactive oxygen species exhibited limited translatability, emerging strategies targeting non-energetic aspects of mitochondrial provide a new therapeutic target with the potential to modify the risk of AD and development. Growing evidence also reveals an important relationship between mitochondrial phenotype and neuroinflammation via cells.Herein glial metabolic reprogramming, we summarize the main class of mitochondrial-based therapeutic strategies AD. Moreover, the difference in their success when translated from preclinical models to clinical trials aimed. key factors that distinguish the response to the intervention of bioenergy, including sex, APOE genotype and cellular diversity in the brain, which discussed.

We proposes that the future development of AD mitochondrial targeted therapy should consider the interaction between bioenergetics and mechanisms of other diseases that may require specific types of targeting cell- to distinguish between neurons and cells of non-neural. In addition, a successful strategy will likely include stratification by metabolic phenotype that varies by gender and genetic risk profile and dynamic change throughout the course of the disease. As the network expands in intracellular mitochondria integration and systems biology level, intended- votes, either, compared to unintended consequences, bad, will be required to achieve the therapeutic potential of mitochondria.

 Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential.
Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Mitochondrial dysfunction in metabolic disorders associated with age.

Aging is a natural biological processes within an organism that is characterized by bioenergetics and downs of life. Mitochondria are important for cellular bioenergetics and thus an important contributor to age-related damage energetics.

In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis makes this organelle major cellular components that dictate the fate of cells. To maintain the quantity and quality, mitochondria undergo several processes such as fission, fusion and mitophagy to remove or replace the faulty mitochondria. While the machine is properly protected bioenergetics, functional decline associated with age and metabolic diseases associated with age is largely the result of a failure in the protective mechanism.

In addition, the byproducts of metabolism such as reactive oxygen species are also helpful in this damaging path. Mitochondrial dysfunction is always considered to be associated with the disease. In addition, studies in recent years have shown that aging contributes to the decay of mitochondrial health by promoting the imbalance in the mitochondrial pathway-arranged keys. Thus, it is important to understand the nexus of mitochondrial dysfunction and age-related diseases. This review focuses on the various aspects of mitochondrial biology and status on the basis of aging and metabolic diseases associated with age. This article is protected by copyright. All rights reserved.

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome)

P100EZ - Ask for price

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample

P100EZ-sample - Ask for price

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10 each
EUR 1005.6

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20 each
EUR 1546.8

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3 each
EUR 523.2

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5 each
EUR 796.8

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T each
EUR 1136.4

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B each
EUR 888

Exosome Isolation Kit

E601E001 20 tests
EUR 2500

Exosome Isolation kit (for serum & plasma)

P101 - Ask for price

Exosome Isolation kit (for serum & plasma)

P101L - Ask for price

Exosome Isolation kit (for serum & plasma)

P101S - Ask for price

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)

P101NGS - Ask for price

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10 each
EUR 1005.6

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20 each
EUR 1546.8

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3 each
EUR 523.2

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5 each
EUR 796.8

Exosome Isolation kit (for cell culture media)

P100 - Ask for price

Exosome Isolation kit (for cell culture media)

P100L - Ask for price

Exosome Isolation kit (for cell culture media)

P100S - Ask for price

Exosome Isolation kit (for stem cell culture media)

P107S - Ask for price

Exosome Isolation kit (for stem cell culture media)

P107 - Ask for price

GPC1 Capture Exosome Isolation Kit

E601E004 20 tests
EUR 2500

CD63 Capture Exosome Isolation Kit

E601E005 20 tests
EUR 2500

CD81 Capture Exosome Isolation Kit

E601E006 20 tests
EUR 2500

Exosome Isolation kit (forHuman Body Fluid)

P121 - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121L - Ask for price

Exosome Isolation kit (forHuman Body Fluid)

P121S - Ask for price

Breast cancer Exosome Isolation Kit

E601E002 20 tests
EUR 2500

EPCAM Capture Exosome Isolation Kit

E601E003 20 tests
EUR 2500

HSP70 Capture Exosome Isolation Kit

E601E007 20 tests
EUR 2500

Custom cell exosome isolation

S101 -
EUR 700

Disease cell exosome isolation

S102 - Ask for price

ExoPure? Isolation Kit   (Urine)

K1240-10 each
EUR 836.4

ExoPure? Isolation Kit   (Urine)

K1240-2 each
EUR 483.6

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530 - Ask for price

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530S - Ask for price

Urine DNA Isolation Kit

K5011150 1 kit
EUR 237

ExoQuick-LP for lipoprotein pre-clear & exosome isolation

EXOLP5A-1 5 reactions
EUR 473

VEX Exosome Isolation Reagent (from serum)

R602 10 ml
EUR 769.2

XCF COMPLETE Exosome and cfDNA Isolation Kit (for Serum and Plasma)

XCF100A-1 20 rxn
EUR 583

VEX Exosome Isolation Reagent (from plasma)

R603 10 ml
EUR 769.2

Reagent for Total Exosome Isolation (Culture Media Supplement)

EIR-02 50 ml
EUR 2485.2
Description: This product is used for isolating exosomes from culture media supplement based on chemical precipitation isolation method.

ExoQuick Exosome Isolation and RNA Purification kit (for Serum and Plasma)

EQ806A-1 20 preps
EUR 493

FitAmp Urine DNA Isolation Kit 

P-1017
  • EUR 474.12
  • EUR 171.60
  • EUR 292.60
  • 100 Samples
  • 50 Samples
  • 100 Samples

ExoQuick Exosome Isolation and RNA Purification kit (for Tissue Culture Media)

EQ806TC-1 10 preps
EUR 493

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50 each
EUR 1083.6

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)

P101EZ - Ask for price

VEX Exosome Isolation Reagent (from cell culture media)

R601 50 ml
EUR 706.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10 each
EUR 796.8

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20 each
EUR 1260

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5 each
EUR 633.6

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample

P101EZ--sample - Ask for price

ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)

EXOCG50A-1 50 ml
EUR 1106

TumorExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1016-100-T each
EUR 874.8

TumorExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1017-100-W each
EUR 888

TumorExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1018-100-B each
EUR 888

GlialExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1022-100-T each
EUR 888

GlialExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1023-100-W each
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GlialExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

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EUR 888

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1019-100-T each
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NeuralExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1020-100-W each
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NeuralExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

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EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T each
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ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W each
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ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B each
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ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T each
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ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W each
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ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T each
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ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W each
EUR 888

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

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Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

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Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

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Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

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ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

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ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

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ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

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ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

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ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

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ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

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ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

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ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

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XCF Exosomal DNA Isolation Kit

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TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

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TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

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TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

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EUR 523.2

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1032-5 each
EUR 796.8

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1033-10 each
EUR 1057.2

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1033-20 each
EUR 1618.8

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3 each
EUR 523.2

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1033-5 each
EUR 796.8

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1034-10 each
EUR 1005.6

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1034-20 each
EUR 1495.2

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3 each
EUR 398.4

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1034-5 each
EUR 777.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1035-10 each
EUR 1005.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1035-20 each
EUR 1495.2

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3 each
EUR 516

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1035-5 each
EUR 777.6

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1036-10 each
EUR 1005.6

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1036-20 each
EUR 1546.8

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3 each
EUR 516

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1036-5 each
EUR 777.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1037-10 each
EUR 1005.6

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1037-20 each
EUR 1546.8

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3 each
EUR 516

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1037-5 each
EUR 777.6

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 490

Fluorescent Exosome Standard (Urine )

ESF-15 100 µg
EUR 2067.6
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

ExoFACS? Kit for Urine Exosomes

K1235-20 each
EUR 973.2

Exosome Purification and Detection Kit (Urine)

abx290027-25tests 25 tests
EUR 777.6

ExoStd? Urine Fluorescent Exosome Standard

M1075-100 each
EUR 907.2

Lyophilized Exosome Standard (Human Urine)

ESL-29 30 µgx2 vials
EUR 1620
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

ExoQuick ULTRA EV Isolation Kit for Serum and Plasma

EQULTRA-20A-1 20 reactions
EUR 941

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 493.2

Rna Isolation Kit

11828665001 EACH
EUR 378.62

ExoPure? Isolation Kit   (Cell Media)

K1237-10 each
EUR 796.8

ExoPure? Isolation Kit   (Cell Media)

K1237-2 each
EUR 470.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-10 each
EUR 836.4

ExoPure? Isolation Kit   (Bio Fluids)

K1241-2 each
EUR 483.6

ExoQuick-TC ULTRA EV Isolation Kit for Tissue Culture Media

EQULTRA-20TC-1 20 reactions
EUR 518

miRNA Isolation Kit

FAMIK--001 Rxns: 100
EUR 398.4
Description: Contents of the kit:
  • Rxns:100Lysis
  • Buffer-10 ml
  • Acid-Phenol-10 ml
  • RNA Column and Collection Tube-100 sets
  • Wash Buffer-10 ml
  • Release Buffer-0.5 ml

miRNA Isolation Kit

FAMIK--002 Rxns: 50
EUR 267.6

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-10 each
EUR 836.4

ExoPure? Isolation Kit   (Serum, Plasma)

K1238-2 each
EUR 470.4

MicroRNA Isolation Kit

KS341025 1 kit
EUR 247

Endosome Isolation Kit

P528 - Ask for price

Microsome Isolation Kit

K249-50 each
EUR 633.6

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 2 vials)

M1044-2 each
EUR 718.8

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4 each
EUR 1090.8

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials)

M1044-6 each
EUR 1546.8


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