Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Alzheimer’s disease (AD) is the leading cause of dementia. So far, 99.6% of the clinical trials, including those targeting the energy metabolism, have failed to mobilize disease-modifying properties. altered mitochondrial function and disorders of the brain bioenergy systems have long-documented as early events during the development of AD pathology.

The latest progress: While therapeutic approaches that directly promote mitochondrial bioenergetic machine or eliminating reactive oxygen species exhibited limited translatability, emerging strategies targeting non-energetic aspects of mitochondrial provide a new therapeutic target with the potential to modify the risk of AD and development. Growing evidence also reveals an important relationship between mitochondrial phenotype and neuroinflammation via cells.Herein glial metabolic reprogramming, we summarize the main class of mitochondrial-based therapeutic strategies AD. Moreover, the difference in their success when translated from preclinical models to clinical trials aimed. key factors that distinguish the response to the intervention of bioenergy, including sex, APOE genotype and cellular diversity in the brain, which discussed.

We proposes that the future development of AD mitochondrial targeted therapy should consider the interaction between bioenergetics and mechanisms of other diseases that may require specific types of targeting cell- to distinguish between neurons and cells of non-neural. In addition, a successful strategy will likely include stratification by metabolic phenotype that varies by gender and genetic risk profile and dynamic change throughout the course of the disease. As the network expands in intracellular mitochondria integration and systems biology level, intended- votes, either, compared to unintended consequences, bad, will be required to achieve the therapeutic potential of mitochondria.

 Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential.
Mitochondria Targeted Therapeutics for Alzheimer’s Disease: The Good. The Bad. The Potential.

Mitochondrial dysfunction in metabolic disorders associated with age.

Aging is a natural biological processes within an organism that is characterized by bioenergetics and downs of life. Mitochondria are important for cellular bioenergetics and thus an important contributor to age-related damage energetics.

In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis makes this organelle major cellular components that dictate the fate of cells. To maintain the quantity and quality, mitochondria undergo several processes such as fission, fusion and mitophagy to remove or replace the faulty mitochondria. While the machine is properly protected bioenergetics, functional decline associated with age and metabolic diseases associated with age is largely the result of a failure in the protective mechanism.

In addition, the byproducts of metabolism such as reactive oxygen species are also helpful in this damaging path. Mitochondrial dysfunction is always considered to be associated with the disease. In addition, studies in recent years have shown that aging contributes to the decay of mitochondrial health by promoting the imbalance in the mitochondrial pathway-arranged keys. Thus, it is important to understand the nexus of mitochondrial dysfunction and age-related diseases. This review focuses on the various aspects of mitochondrial biology and status on the basis of aging and metabolic diseases associated with age. This article is protected by copyright. All rights reserved.

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-25
EUR 827

ExoPure? Reagent (Overall Exosome Isolation, urine)

M1003-50
EUR 903

ExoPure? Isolation Kit   (Urine)

K1240-10
EUR 697

ExoPure? Isolation Kit   (Urine)

K1240-2
EUR 403

Urine DNA Isolation Kit

K5011150 1 kit
EUR 256

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, colorimetric assay)

M1004-100-T
EUR 947

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, luminometric assay)

M1005-100-W
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, plasma, urine, fluorometric assay)

M1006-100-B
EUR 740

Exosome Isolation kit (for serum & plasma)

P101 NULL
EUR 0

Exosome Isolation kit (for serum & plasma)

P101L NULL
EUR 0

Exosome Isolation kit (for serum & plasma)

P101S NULL
EUR 0

Exo-Urine EV Isolation Kit

EXOU100A-1 2 x 5 reactions
EUR 551

FitAmp Urine DNA Isolation Kit

P-1017 100 Samples
EUR 395.1
Description: kits suitable for this type of research

Exosome Isolation kit (for serum & plasma -Exosome-RNA-NGS)

P101NGS NULL
EUR 0

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome)

P100EZ NULL
EUR 0

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-10
EUR 838

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-20
EUR 1289

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-3
EUR 436

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum)

M1038-5
EUR 664

Exosome Isolation kit (for cell culture media)

P100 NULL
EUR 0

Exosome Isolation kit (for cell culture media)

P100L NULL
EUR 0

Exosome Isolation kit (for cell culture media)

P100S NULL
EUR 0

Fluorescent Exosome Standard (Urine )

ESF-15 100 µg
EUR 1723
Description: Fluorescent exosomes are labeled with green dye, which offer a stable fluorescent labeling.

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample

P100EZ-sample NULL
EUR 0

Exosome Purification and Detection Kit (Urine)

abx290027-25tests 25 tests
EUR 648
  • Shipped within 2-3 weeks.

Exosome Isolation kit (for stem cell culture media)

P107 NULL
EUR 0

Exosome Isolation kit (for stem cell culture media)

P107S NULL
EUR 0

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 10 reactions)

M1039-10
EUR 838

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 20 reactions)

M1039-20
EUR 1289

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions)

M1039-3
EUR 436

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 5 reactions)

M1039-5
EUR 664

Lyophilized Exosome Standard (Human Urine)

ESL-29 30 µgx2 vials
EUR 1350
Description: Lyophilized exosomes can be used as control standards for FACS, WB, ELISA and as calibration standards for quantitation of exosome-derived markers from biological samples.

ExoStd? Urine Fluorescent Exosome Standard

M1075-100
EUR 756

Exosome Isolation kit (forHuman Body Fluid)

P121 NULL
EUR 0

Exosome Isolation kit (forHuman Body Fluid)

P121L NULL
EUR 0

Exosome Isolation kit (forHuman Body Fluid)

P121S NULL
EUR 0

Reagent for Total Exosome Isolation (Culture Media Supplement)

EIR-02 50 ml
EUR 2071
Description: This product is used for isolating exosomes from culture media supplement based on chemical precipitation isolation method.

ExoQuick-LP for lipoprotein pre-clear & exosome isolation

EXOLP5A-1 5 reactions
EUR 533
  • Category: Exosomes

VEX Exosome Isolation Reagent (from serum)

R602 10 ml
EUR 641

VEX Exosome Isolation Reagent (from plasma)

R603 10 ml
EUR 641

ExoQuick Exosome Isolation and RNA Purification kit (for Serum and Plasma)

EQ806A-1 20 preps
EUR 554

ExoQuick Exosome Isolation and RNA Purification kit (for Tissue Culture Media)

EQ806TC-1 10 preps
EUR 554

XCF COMPLETE Exosome and cfDNA Isolation Kit (for Serum and Plasma)

XCF100A-1 20 rxn
EUR 647
  • Category: Exosome

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530 NULL
EUR 0

Easy-Exo Saliva Exosome Isolation Kit, 95% pure

P530S NULL
EUR 0

ExoFACS? Kit for Urine Exosomes

K1235-20
EUR 811

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-10
EUR 664

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-20
EUR 1050

ExoPure? Reagent (Overall Exosome Isolation, biological fluids)

M1001-5
EUR 528

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-25
EUR 827

ExoPure? Reagent (Overall Exosome Isolation, cell media)

M1002-50
EUR 903

TumorExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1016-100-T
EUR 729

TumorExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1017-100-W
EUR 740

TumorExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1018-100-B
EUR 740

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1019-100-T
EUR 756

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1020-100-W
EUR 740

NeuralExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1021-100-B
EUR 740

GlialExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1022-100-T
EUR 740

GlialExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1023-100-W
EUR 740

GlialExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1024-100-B
EUR 740

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome)

P101EZ NULL
EUR 0

ExoPure? Immunoplates (Overall Exosome Isolation, serum, colorimetric assay)

M1007-100-T
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, serum, luminometric assay)

M1008-100-W
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, serum, fluorimetric assay)

M1009-100-B
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1010-100-T
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1011-100-W
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1012-100-B
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, colorimetric assay)

M1013-100-T
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, luminometric assay)

M1014-100-W
EUR 740

ExoPure? Immunoplates (Overall Exosome Isolation, saliva, fluorimetric assay)

M1015-100-B
EUR 740

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, colorimetric assay)

M1025-100-T
EUR 740

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, luminometric assay)

M1026-100-W
EUR 740

Monocytes/PlateletExoPure? Immunoplates (Exosome Isolation, plasma, fluorimetric assay)

M1027-100-B
EUR 740

VEX Exosome Isolation Reagent (from cell culture media)

R601 50 ml
EUR 589

ExoQuant? Overall Exosome Capture and Quantification Assay Kit (Human Urine, Colorimetric)

K1202-100
EUR 968

ExoQuant? Overall Exosome Capture and Quantification Assay Kit (Human Urine, Luminometric)

K1207-100
EUR 968

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample

P101EZ--sample NULL
EUR 0

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 2 vials)

M1044-2
EUR 599

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials)

M1044-4
EUR 909

ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 6 vials)

M1044-6
EUR 1289

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 2 vials)

M1045-2
EUR 707

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials)

M1045-4
EUR 1137

ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 6 vials)

M1045-6
EUR 1572

ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)

EXOCG50A-1 50 ml
EUR 1181
  • Category: Exosomes

Mammalian Mitochondria Isolation Kit for Tissue

abx098857-50rxns 50 rxns
EUR 411
  • Shipped within 5-10 working days.

ExoDNAUC? Circulating and Exosome-associated DNA Extraction Kit (Urine/Cell Media, 20 reactions)

K1231-20
EUR 718

ExoDNAUC? Circulating and Exosome-associated DNA Extraction Kit (Urine/Cell Media, 40 reactions)

K1231-40
EUR 1061

ExoFectin Plasmid DNA-into-Exosome Kit (DNA transfection kit for exosome)

P402 NULL
EUR 0

ExoStep Urine

ExoS-25-U9 25 test
EUR 550.5

LH (Urine) ELISA Kit

DEIA2231 96T
EUR 559
Description: The LH (Urine) ELISA is an enzyme immunoassay for the quantitative in vitro diagnostic measurement of LH in urine. This test is used to detect the midcycle LH surge in urine, which is an aid in predicting the time of ovulation.

Urine Creatinine Detection Kit

SKT-200-192 2 plates of 96 wells
EUR 342
  • Creatinine (2-amino-1-methyl-5H-imadazol-4-one) is a metabolite of phosphocreatine (p-creatine), a molecule used as a store for high-energy phosphate that can be utilized by tissues for the production of ATP (1). Creatine either comes from the diet o
  • Show more
Description: Direct Detection kit used for quantitative measuring creatinine in Urine samples from Human, Monkey, Dog, Rat

Mammalian Mitochondria Isolation Kit for Cultured Cells

20-abx098856
  • EUR 105.00
  • EUR 411.00
  • 2 rxns
  • 50 rxns
  • Shipped within 5-10 working days.

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1030-10
EUR 838

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1030-20
EUR 1289

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1030-3
EUR 441

ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1030-5
EUR 664

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 10 reactions)

M1031-10
EUR 838

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 20 reactions)

M1031-20
EUR 1289

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions)

M1031-3
EUR 436

ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 5 reactions)

M1031-5
EUR 664

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1032-10
EUR 881

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1032-20
EUR 1349

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1032-3
EUR 436

TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1032-5
EUR 664

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 10 reactions)

M1033-10
EUR 881

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 20 reactions)

M1033-20
EUR 1349

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions)

M1033-3
EUR 436

TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 5 reactions)

M1033-5
EUR 664

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1034-10
EUR 838

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1034-20
EUR 1246

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1034-3
EUR 332

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1034-5
EUR 648

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 10 reactions)

M1035-10
EUR 838

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 20 reactions)

M1035-20
EUR 1246

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions)

M1035-3
EUR 430

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 5 reactions)

M1035-5
EUR 648

Mitochondria Isolation Kit

AR0156 1 kit
EUR 106

miRNA Isolation Kit

FAMIK--001 Rxns: 100
EUR 332
Description: Contents of the kit:
  • Rxns:100Lysis
  • Buffer-10 ml
  • Acid-Phenol-10 ml
  • RNA Column and Collection Tube-100 sets
  • Wash Buffer-10 ml
  • Release Buffer-0.5 ml

miRNA Isolation Kit

FAMIK--002 Rxns: 50
EUR 223

miRNA Isolation Kit

FYG304-100P 100 Preps Ask for price

Microsome Isolation Kit

K249-50
EUR 528

Preadipocyte Isolation Kit

K583-5
EUR 533

MicroRNA Isolation Kit

KS341025 1 kit
EUR 256
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Endosome Isolation Kit

P528 NULL
EUR 0

Mammalian Mitochondria Isolation Kit For Tissue & Cultured Cells

K288-50
EUR 419

Mitochondria Isolation Kit for Tissue and Cultured Cells

KC010100 1 kit
EUR 320
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Nuclei and Cytosol Isolation Kit for Adipose Tissues

P529 NULL
EUR 0

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1036-10
EUR 838

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1036-20
EUR 1289

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1036-3
EUR 430

MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1036-5
EUR 648

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 10 reactions)

M1037-10
EUR 838

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 20 reactions)

M1037-20
EUR 1289

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions)

M1037-3
EUR 430

MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 5 reactions)

M1037-5
EUR 648


Which form a biological membrane lipids tend to forget molecular cell biology. Lack of data on important entities may reflect the difficulty of learning and understanding of their biological role, rather than reveal the lack of importance.